新京都啡肽（苏氨酸-丝氨酸-赖氨酸-酪氨酸-精氨酸），一种新型镇痛肽。
Neo-kyotorphin (Thr-Ser-Lys-Tyr-Arg), a new analgesic peptide.
作者信息
Kiso Y, Kitagawa K, Kawai N, Akita T, Takagi H, Amano H, Fukui K
出版信息
FEBS Lett. 1983 May 8;155(2):281-4. doi: 10.1016/0014-5793(82)80621-2.
PMID:6852239
Abstract
The amino acid sequence of a newly isolated pentapeptide, neo-kyotorphin from bovine brain was synthetically verified to be Thr-Ser-Lys-Tyr-Arg corresponding to the C-terminal portion of hemoglobin alpha-chain. The synthetic neo-kyotorphin showed the dose-dependent analgesia in mice which was approximately equal to that of Leu-enkephalin.
摘要
从牛脑中新分离出的五肽新京都啡肽的氨基酸序列经合成验证为苏氨酸-丝氨酸-赖氨酸-酪氨酸-精氨酸，与血红蛋白α链的C末端部分相对应。合成的新京都啡肽在小鼠中显示出剂量依赖性镇痛作用，其镇痛效果与亮氨酸脑啡肽大致相当。
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