UDP-糖转运至细胞内囊泡的机制。UDP-GlcNAc/UDP和UDP-Gal/UDP反向转运的存在。
Mechanism of UDP-sugar transport into intracellular vesicles. Occurrence of UDP-GlcNAc/UDP and UDP-Gal/UDP antiports.
作者信息
Cecchelli R, Cacan R, Verbert A
出版信息
FEBS Lett. 1986 Nov 24;208(2):407-12. doi: 10.1016/0014-5793(86)81058-4.
The mechanism of translocation of UDP-GlcNAc, UDP-Gal and UDP-Glc into intracellular vesicles has been studied using thymocytes whose plasma membranes have been permeabilized with isotonic ammonium chloride. It has been previously shown that the intracellular vesicles have specific carriers for UDP-GlcNAc and UDP-Gal. We now report that the translocation of these two sugar nucleotides occurs via UDP-GlcNAc/UDP and UDP-Gal/UDP antiports. The entry of UDP-GlcNAc or UDP-Gal into vesicles was specifically dependent on the exit of UDP from these vesicles. In contrast, no antiport mechanism has been recovered with UDP-Glc for which no transport and accumulation into intracellular vesicles were observed.
利用经等渗氯化铵通透化处理的胸腺细胞，研究了UDP-GlcNAc、UDP-Gal和UDP-Glc转运至细胞内囊泡的机制。先前已经表明，细胞内囊泡具有UDP-GlcNAc和UDP-Gal的特异性载体。我们现在报告，这两种糖核苷酸的转运是通过UDP-GlcNAc/UDP和UDP-Gal/UDP反向转运体进行的。UDP-GlcNAc或UDP-Gal进入囊泡特别依赖于UDP从这些囊泡中排出。相比之下，未发现UDP-Glc存在反向转运机制，未观察到其向细胞内囊泡的转运和积累。
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