The cardioprotective effect of decoction on patients with chronic heart failure based on the levels of soluble interleukin 1 receptor-like 1.

OBJECTIVE

The purpose of this study was to evaluate the protective effect of decoction on patients with chronic heart failure (CHF) based on the levels of soluble interleukin 1 receptor-like 1 (ST2).

METHODS

We included a total of 80 outpatients and inpatients with CHF who were undergoing treatment at the Shanghai Municipal Hospital of Traditional Chinese Medicine between March 2020 and March 2022. We randomly divided them into the observation group ( = 40) and the control group ( = 40). Patients in the control group received treatments as per conventional Western medicine, while those in the observation group were treated with the decoction in conjunction with Western medicine for eight consecutive weeks. We then compared the pre- and post-treatment levels of ST2 and N-terminal pro-brain natriuretic peptide (NT-proBNP) of the patients in the two groups.

RESULTS

There were no significant differences in the pre-treatment levels of ST2 and NT-proBNP indexes between the two groups ( > 0.05), while the post-treatment comparison between the two groups in terms of ST2 and NT-proBNP levels suggested that the effect in the observation group was better, with statistical significance ( < 0.05).

CONCLUSION

decoction was beneficial in patients with CHF, suggesting that it could be a promising and effective method for the treatment of CHF.