Said Marwa, Ghoneim Baker, Jones Jennifer, Tawfick Wael
School of Medicine, University of Galway, Ireland.
National Institute for Prevention and Cardiovascular Health, Ireland.
Prev Med Rep. 2023 Sep 18;36:102424. doi: 10.1016/j.pmedr.2023.102424. eCollection 2023 Dec.
Sedentary behavior has recently emerged as a risk factor for cardiometabolic diseases. The objective of this review was to assess the relationship between sedentary behavior and peripheral arterial disease (PAD). Using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines, we performed an electronic search across databases including Cochrane Central Register of Controlled Trials, Embase, MEDLINE (Ovid), CINHAL and PubMed to identify studies focusing on sedentary behavior and PAD. A total of 678 records fulfilled eligibility; 166 duplicates were removed, 487 were excluded at the title and abstract level and 15 studies were excluded at the full article level. Thus, our review comprised 10 studies of 20,064 patients with mean age 67.4 years. The average sedentary time was 544.9 min/day. The current review findings indicate that patients with PAD exhibited prolonged periods of sedentary behavior. Furthermore, sedentary behavior among patients with PAD was associated with lower survival rates. The included studies also reported varied outcomes regarding walking distance with some showing an association between reduced sedentary behavior and increased total walking distance. A randomized controlled trial in this review highlighted that reducing sedentary time among patients with PAD improved walking distance. Therefore, the connection between sedentary behavior and PAD seems to be bidirectional. Sedentary time could contribute to PAD development, and PAD-related symptoms may lead to prolonged sedentary behavior. A call for research investigating the link between PAD and sedentary time. Additionally, intervention studies are needed to target the reduction of sedentary time in patients with PAD.
久坐行为最近已成为心脏代谢疾病的一个风险因素。本综述的目的是评估久坐行为与外周动脉疾病（PAD）之间的关系。我们按照系统评价和Meta分析的首选报告项目（PRISMA）指南，在包括Cochrane对照试验中心注册库、Embase、MEDLINE（Ovid）、护理学与健康领域数据库（CINHAL）和PubMed在内的多个数据库中进行了电子检索，以识别关注久坐行为和PAD的研究。共有678条记录符合纳入标准；去除了166条重复记录，在标题和摘要层面排除了487条记录，在全文层面排除了15项研究。因此，我们的综述纳入了10项研究，涉及20,064名平均年龄为67.4岁的患者。平均久坐时间为每天544.9分钟。当前的综述结果表明，PAD患者表现出较长时间的久坐行为。此外，PAD患者中的久坐行为与较低的生存率相关。纳入的研究还报告了关于步行距离的不同结果，一些研究表明减少久坐行为与增加总步行距离之间存在关联。本综述中的一项随机对照试验强调，减少PAD患者的久坐时间可改善步行距离。因此，久坐行为与PAD之间的联系似乎是双向的。久坐时间可能导致PAD的发展，而与PAD相关的症状可能导致久坐行为时间延长。呼吁开展研究调查PAD与久坐时间之间的联系。此外，需要进行干预研究，以减少PAD患者的久坐时间。
