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观点:对于因后纵韧带骨化症(OPLL)而进行颈椎手术,术中三重神经生理监测(IONM)应被视为标准治疗方法(SOC)。

Perspective: Triple intraoperative neurophysiological monitoring (IONM) should be considered the standard of care (SOC) for performing cervical surgery for ossification of the posterior longitudinal ligament (OPLL).

作者信息

Epstein Nancy E, Agulnick Marc A

机构信息

Professor of Clinical Neurosurgery, School of Medicine, State University of NY at Stony Brook and Editor-in-Chief Surgical Neurology International NY and c/o Dr. Marc Agulnick 1122 Franklin Avenue Suite 106, Garden City, New York, United States.

Assistant Clinical Professor of Orthopedic Surgery, NYU Hospital Long Island c/o Dr. Marc Agulnick 1122 Franklin Avenue Suite 106, Garden City, NY, United States.

出版信息

Surg Neurol Int. 2023 Sep 15;14:336. doi: 10.25259/SNI_710_2023. eCollection 2023.

Abstract

BACKGROUND

Triple Intraoperative Neurophysiological Monitoring (IONM) should be considered the standard of care (SOC) for performing cervical surgery for Ossification of the Posterior Longitudinal Ligament (OPLL). IONM's three modalities and their alerts include; Somatosensory Evoked Potentials (SEP: =/> 50% amplitude loss; =/>10% latency loss), Motor Evoked Potentials (MEP: =/> 70% amplitude loss; =/>10-15% latency loss), and Electromyography (loss of EMG, including active triggered EMG (t-EMG)).

METHODS

During cervical OPLL operations, the 3 IONM alerts together better detect intraoperative surgical errors, enabling spine surgeons to immediately institute appropriate resuscitative measures and minimize/avoid permanent neurological deficits/injuries.

RESULTS

This focused review of the literature regarding cervical OPLL surgery showed that SEP, MEP, and EMG monitoring used together better reduced the incidence of new nerve root (e.g., mostly C5 but including other root palsies), brachial plexus injuries (i.e., usually occurring during operative positioning), and/or spinal cord injuries (i.e., one study of OPLL patients documented a reduced 3.79% incidence of cord deficits utilizing triple IONM vs. a higher 14.06% frequency of neurological injuries occurring without IONM).

CONCLUSIONS

Triple IONM (i.e, SEP, MEP, and EMG) should be considered the standard of care (SOC) for performing cervical OPLL surgery. However, the positive impact of IONM on OPLL surgical outcomes critically relies on spinal surgeons' immediate response to SEP, MEP, and/or EMG alerts/significant deterioration with appropriate resuscitative measures to limit/avert permanent neurological deficits.

摘要

背景

术中三重神经生理监测(IONM)应被视为进行后纵韧带骨化症(OPLL)颈椎手术的标准治疗方法(SOC)。IONM的三种模式及其警报包括:体感诱发电位(SEP:波幅损失≥50%;潜伏期损失≥10%)、运动诱发电位(MEP:波幅损失≥70%;潜伏期损失≥10 - 15%)以及肌电图(肌电图信号消失,包括主动触发肌电图(t - EMG))。

方法

在颈椎OPLL手术过程中,这三种IONM警报共同作用能更好地检测术中手术失误,使脊柱外科医生能够立即采取适当的复苏措施,将永久性神经功能缺损/损伤降至最低或避免发生。

结果

对有关颈椎OPLL手术的文献进行的这项重点综述表明,联合使用SEP、MEP和肌电图监测能更好地降低新发神经根损伤(例如,主要是C5,但包括其他神经根麻痹)、臂丛神经损伤(即在手术体位摆放期间通常会发生)和/或脊髓损伤的发生率(即,一项对OPLL患者的研究记录显示,与未使用IONM时较高的14.06%的神经损伤发生率相比,使用三重IONM可使脊髓功能缺损的发生率降低至3.79%)。

结论

三重IONM(即SEP、MEP和肌电图)应被视为进行颈椎OPLL手术的标准治疗方法(SOC)。然而,IONM对OPLL手术结果的积极影响关键取决于脊柱外科医生对SEP、MEP和/或肌电图警报/显著恶化情况的立即反应,并采取适当的复苏措施以限制/避免永久性神经功能缺损。

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