Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Int J Chron Obstruct Pulmon Dis. 2023 Oct 2;18:2163-2177. doi: 10.2147/COPD.S419634. eCollection 2023.
PURPOSE: Chronic obstructive pulmonary disease (COPD) is a prevalent respiratory condition characterized by chronic airway inflammation, where macrophages from the innate immune system may exert a pivotal influence. Our study aimed to summarize the present state of knowledge and to identify the focal points and emerging developments regarding macrophages associated with COPD through bibliometrics. METHODS: Publications regarding research on macrophages associated with COPD from January 1, 2011, to January 1, 2022, were retrieved from the Science Citation Index-Expanded (SCI-E) which is part of the Web of Science database. In total, 1521 publications were analyzed using bibliometric methodology. VOSviewer was used to analyze the annual publications, countries, institutions, authors, journals, and research hotspots. RESULTS: Based on the bibliometric analysis, publications relating to macrophages associated with COPD tended to increase from 2011 to 2022. The United States was the largest producer and most influential country in this field. Research during the past decade has focused on inflammation in the lungs. Most previous studies have mainly focused on the mechanisms that promote the initiation and progression of COPD. Macrophage-related oxidative stress and immunity, communication between macrophages and epithelial cells, and interventions for acute exacerbations have become the focus of more recent studies and will become a hot topic in the future. CONCLUSION: Global research on macrophage-associated COPD has been growing rapidly in the past decade. The hot topics in this field gradually tended to shift focus from "inflammation" to "oxidative stress", "epithelial-cells", and "exacerbations". The significance of macrophages in coordinating immune responses, interacting with other cells, and exhibiting dysregulated capacities has attracted increasing attention to COPD pathogenesis. The adoption of new technologies may provide a more promising and comprehensive understanding of the specific role of macrophages in COPD in the future.
目的：慢性阻塞性肺疾病（COPD）是一种常见的呼吸系统疾病，其特征为慢性气道炎症，固有免疫系统中的巨噬细胞可能发挥关键作用。我们的研究旨在通过文献计量学方法总结与 COPD 相关的巨噬细胞的现有知识状态，并确定其焦点和新的发展方向。
方法：从 Web of Science 数据库的科学引文索引扩展版（SCI-E）中检索了 2011 年 1 月 1 日至 2022 年 1 月 1 日期间与 COPD 相关的巨噬细胞研究的文献，共分析了 1521 篇文献。使用文献计量学方法分析了年度出版物、国家、机构、作者、期刊和研究热点。
结果：基于文献计量分析，与 COPD 相关的巨噬细胞相关出版物的数量从 2011 年到 2022 年呈上升趋势。美国是该领域最大的生产国和最具影响力的国家。过去十年的研究重点是肺部炎症。之前的大多数研究主要集中在促进 COPD 发生和发展的机制上。与巨噬细胞相关的氧化应激和免疫、巨噬细胞与上皮细胞之间的通讯以及急性加重的干预措施已成为最近研究的焦点，并将成为未来的热门话题。
结论：过去十年，全球对巨噬细胞相关 COPD 的研究迅速增长。该领域的热点话题逐渐从“炎症”转向“氧化应激”、“上皮细胞”和“加重”。巨噬细胞在协调免疫反应、与其他细胞相互作用以及表现出失调能力方面的重要性引起了人们对 COPD 发病机制的越来越多的关注。新技术的采用可能为未来更深入地了解巨噬细胞在 COPD 中的特定作用提供更有前途和全面的认识。
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