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近红外触发的光动力疗法治疗创伤性异位骨化：使用靶向II型胶原蛋白的光敏剂

NIR-triggered photodynamic therapy of traumatic heterotopic ossification with a type II collagen-targeted photosensitizer.

作者信息

Wang Zheng, Sun Chao, Yu Yifeng, Zhang Dong, Qi Baiwen, Li Zonghuan, Yi Xinzeyu, Yu Aixi

机构信息

Department of Orthopedics Trauma and Microsurgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, China.

出版信息

Mater Today Bio. 2023 Sep 27;23:100822. doi: 10.1016/j.mtbio.2023.100822. eCollection 2023 Dec.

DOI:10.1016/j.mtbio.2023.100822
PMID:37810751
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10550814/
Abstract

Traumatic heterotopic ossification (HO) represents an intractable sequela following trauma with no currently effective prophylaxis or treatment. Photodynamic therapy (PDT) is a non-invasive treatment for various proliferative diseases. However, the specific effects of PDT on HO development remain unclear. In this study, the therapeutic potential of a near-infrared (NIR) probe-WL-808, composed of type II collagen-binding peptide (WYRGRL) and a PDT photosensitizer (IR-808), was evaluated for the innovative HO-targeted PDT approach. studies indicated that WL-808 could induce chondrocyte apoptosis and inhibit cell viability through ROS generation under NIR excitation. , the efficacy of WL-808-mediated PDT was tested on the tenotomy HO model mice. WL-808 specifically targeted the type II collagen cartilaginous template of HO, promoting cell apoptosis and enhancing extracellular matrix (ECM) degradation under 808 nm NIR excitation, which inhibited the final ectopic bone formation. Moreover, no obvious toxicity or side effects were detected after treatment with WL-808. Taken together, WL-808-mediated PDT significantly diminished ectopic cartilage and subsequent bone formation, providing a new perspective for HO prophylaxis and treatment.

摘要

创伤性异位骨化（HO）是创伤后一种难以治疗的后遗症，目前尚无有效的预防或治疗方法。光动力疗法（PDT）是一种针对各种增殖性疾病的非侵入性治疗方法。然而，PDT对HO发展的具体影响仍不清楚。在本研究中，评估了一种由II型胶原结合肽（WYRGRL）和PDT光敏剂（IR-808）组成的近红外（NIR）探针-WL-808在创新的HO靶向PDT方法中的治疗潜力。研究表明，WL-808在近红外激发下可通过产生活性氧诱导软骨细胞凋亡并抑制细胞活力。此外，在肌腱切断术HO模型小鼠上测试了WL-808介导的PDT的疗效。WL-808特异性靶向HO的II型胶原软骨模板，在808nm近红外激发下促进细胞凋亡并增强细胞外基质（ECM）降解，从而抑制最终的异位骨形成。此外，用WL-808治疗后未检测到明显的毒性或副作用。综上所述，WL-808介导的PDT显著减少了异位软骨和随后的骨形成，为HO的预防和治疗提供了新的视角。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/06a9ecf7f8f5/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/1992f25e095d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/93dd1cf7306e/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/e476b49b117e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/3475b56a8cb3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/0a2ae7e0d7d2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/ce5a329bb9dc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/c24544054097/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/dc79091911f2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/f0d68badbf56/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/06a9ecf7f8f5/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/1992f25e095d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/93dd1cf7306e/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/e476b49b117e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/3475b56a8cb3/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/0a2ae7e0d7d2/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/ce5a329bb9dc/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/c24544054097/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/dc79091911f2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/f0d68badbf56/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cafe/10550814/06a9ecf7f8f5/gr8.jpg

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J Am Chem Soc. 2023 Aug 16;145(32):17881-17891. doi: 10.1021/jacs.3c04981. Epub 2023 Aug 2.
2
Thermosensitive nanocomposite components for combined photothermal-photodynamic therapy in liver cancer treatment.用于肝癌治疗的光热-光动力联合治疗的热敏型纳米复合材料组件。
Colloids Surf B Biointerfaces. 2023 Jun;226:113317. doi: 10.1016/j.colsurfb.2023.113317. Epub 2023 Apr 13.
3
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Int J Biol Sci. 2025 Jan 1;21(2):544-564. doi: 10.7150/ijbs.102297. eCollection 2025.
4
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J Inflamm Res. 2024 Aug 23;17:5587-5598. doi: 10.2147/JIR.S477382. eCollection 2024.
利拉鲁肽限制多柔比星诱导的大鼠性腺毒性后免疫原性细胞死亡介导的 ROS 传播和 PI3K/AKT 失活：经典 Hedgehog 轨迹的参与。
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4
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