乙醇对大鼠神经肌肉功能的影响。它与阿库氯铵的相互作用。

Effect of ethanol on neuromuscular function in rats. Its interaction with alcuronium.

作者信息

Borges R, Feria M, Díaz E, Rodríguez Méndez S A, Boada J

出版信息

Gen Pharmacol. 1986;17(5):569-72. doi: 10.1016/0306-3623(86)90095-9.

Abstract

The effect of chronic ethanol intake on neuromuscular function has been analyzed by using a rat tibial muscle preparation. The time-course of single twitches, trains-of-four, tetanus and post-tetanic facilitation with and without blockade with alcuronium was evaluated. A decrease in these parameters was observed, being more pronounced in ethanol fed rats during 10 than 30 days. The twitch was the most affected parameter. After recovery of alcuronium blockade, the depressant effects of ethanol were completely reversed. These data suggest that low but sustained ethanol blood levels causes evident alterations of neuromuscular function due, probably, to a postjunctional action.

摘要

通过使用大鼠胫骨肌标本，分析了长期摄入乙醇对神经肌肉功能的影响。评估了单次抽搐、四个成串刺激、强直收缩以及强直后易化在使用阿库氯铵阻断和未阻断情况下的时间进程。观察到这些参数有所下降，在乙醇喂养10天的大鼠中比30天的大鼠更为明显。抽搐是受影响最严重的参数。在阿库氯铵阻断作用恢复后，乙醇的抑制作用完全逆转。这些数据表明，低水平但持续的乙醇血药浓度可能由于接头后作用导致神经肌肉功能出现明显改变。