西咪替丁对十二指肠溃疡和胃溃疡愈合及复发的影响。
Effects of cimetidine on the healing and recurrence of duodenal ulcers and gastric ulcers.
作者信息
Tatsuta M, Iishi H, Okuda S
出版信息
Gut. 1986 Oct;27(10):1213-8. doi: 10.1136/gut.27.10.1213.
The effects of cimetidine on the healing and recurrence of duodenal ulcers and gastric ulcers were compared. The extent of the acid secreting areas was examined by the endoscopic Congo red methylene blue test. Using the extent of acid secreting areas gastric ulcers were classified into ulcers with and without extensive acid secreting areas. Duodenal ulcers were all associated with extensive acid secreting areas. The gastric acid outputs in the basal state and after maximal stimulation with gastrin were highest in duodenal ulcers, and lowest in gastric ulcers without extensive acid secreting areas. Cimetidine treatment significantly promoted the healing of duodenal ulcers and gastric ulcers with extensive acid secreting areas when compared with placebo, but not of the gastric ulcers without extensive acid secreting areas. Cimetidine also significantly diminished the recurrence of duodenal ulcers, but not gastric ulcers with and without extensive acid secreting areas. These findings indicate that in Japan cimetidine promotes the healing of duodenal and gastric ulcers associated with high gastric acid production and prevents recurrence of duodenal ulcers, but has little or no influence on the healing and recurrence of gastric ulcers associated with low acid secretion.
比较了西咪替丁对十二指肠溃疡和胃溃疡愈合及复发的影响。通过内镜刚果红亚甲蓝试验检查胃酸分泌区域的范围。根据胃酸分泌区域的范围，胃溃疡分为有广泛胃酸分泌区域的溃疡和无广泛胃酸分泌区域的溃疡。十二指肠溃疡均与广泛的胃酸分泌区域相关。基础状态下及用胃泌素最大刺激后的胃酸分泌量在十二指肠溃疡中最高，在无广泛胃酸分泌区域的胃溃疡中最低。与安慰剂相比，西咪替丁治疗显著促进了十二指肠溃疡和有广泛胃酸分泌区域的胃溃疡的愈合，但对无广泛胃酸分泌区域的胃溃疡无效。西咪替丁还显著减少了十二指肠溃疡的复发，但对有和无广泛胃酸分泌区域的胃溃疡复发均无影响。这些发现表明，在日本，西咪替丁促进了与高胃酸分泌相关的十二指肠溃疡和胃溃疡的愈合，并预防了十二指肠溃疡的复发，但对与低胃酸分泌相关的胃溃疡的愈合和复发几乎没有影响。
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