Department of Medical Physics, Institute of Health Sciences, Dokuz Eylül University, Izmir, Turkey.
Department of Radiology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyon, Turkey.
Brain Dev. 2024 Jan;46(1):35-43. doi: 10.1016/j.braindev.2023.09.003. Epub 2023 Oct 7.
We investigated the volumetric differences in cortical and subcortical structures between patients with complex febrile seizure (FS) and recurrent simple FS. We aimed to identify the brain morphological patterns of children with complex FS.
Twenty-five patients with complex FS and age- and sex-matched 25 patients with recurrent simple FS with structural magnetic resonance imaging (MRI) scans were studied. Cortical volumetric analysis was performed using a voxel-based morphometry method with the CAT12 toolbox within SPM12. FSL-FIRST was used to obtain volume measures of subcortical deep grey matter structures (amygdala, caudate nucleus, thalamus, nucleus accumbens, putamen, globus pallidus, and hippocampus). The volumetric asymmetry index (AI) and laterality index (LI) were calculated for each subcortical structure.
Compared with recurrent simple FS, complex FS demonstrated lower volume in the left putamen (p = .003) and right nucleus accumbens (p = .001). Additionally, patients with complex FS presented a higher magnitude of AI of the nucleus accumbens (p < .001) compared with recurrent simple FS.
The findings indicate that volumetric analysis may be a useful marker for the detection of FS-induced changes that reflect microstructural alterations. This study is the first to report on alterations in the putamen and nucleus accumbens in FS.
我们研究了复杂热性惊厥（FS）和复发性单纯 FS 患者皮质和皮质下结构的体积差异。我们旨在确定复杂 FS 患儿的脑形态模式。
对 25 例复杂 FS 患者和年龄、性别匹配的 25 例复发性单纯 FS 患者进行结构磁共振成像（MRI）扫描。采用基于体素的形态学方法（VBM），使用 CAT12 工具包在 SPM12 中进行皮质体积分析。使用 FSL-FIRST 获得皮质下深部灰质结构（杏仁核、尾状核、丘脑、伏隔核、壳核、苍白球和海马）的体积测量值。计算每个皮质下结构的体积不对称指数（AI）和偏侧性指数（LI）。
与复发性单纯 FS 相比，复杂 FS 患者左壳核（p=0.003）和右伏隔核（p=0.001）体积减小。此外，与复发性单纯 FS 相比，复杂 FS 患者的伏隔核 AI 更大（p<0.001）。
这些发现表明，体积分析可能是检测 FS 引起的变化的有用标志物，这些变化反映了微观结构的改变。本研究首次报道了 FS 中壳核和伏隔核的改变。
