Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, 560029, Karnataka, India.
Coma Science Group and GIGA - Consciousness, University of Liege, Liege, 4000, Belgium.
Sci Rep. 2022 Feb 28;12(1):3267. doi: 10.1038/s41598-022-07173-9.
Complex febrile seizures (CFS), a subset of paediatric febrile seizures (FS), have been studied for their prognosis, epileptogenic potential and neurocognitive outcome. We evaluated their functional connectivity differences with simple febrile seizures (SFS) in children with recent-onset FS. Resting-state fMRI (rs-fMRI) datasets of 24 children with recently diagnosed FS (SFS-n = 11; CFS-n = 13) were analysed. Functional connectivity (FC) was estimated using time series correlation of seed region-to-whole-brain-voxels and network topology was assessed using graph theory measures. Regional connectivity differences were correlated with clinical characteristics (FDR corrected p < 0.05). CFS patients demonstrated increased FC of the bilateral middle temporal pole (MTP), and bilateral thalami when compared to SFS. Network topology study revealed increased clustering coefficient and decreased participation coefficient in basal ganglia and thalamus suggesting an inefficient-unbalanced network topology in patients with CFS. The number of seizure recurrences negatively correlated with the integration of Left Thalamus (r = - 0.58) and FC of Left MTP to 'Right Supplementary Motor and left Precentral' gyrus (r = - 0.53). The FC of Right MTP to Left Amygdala, Putamen, Parahippocampal, and Orbital Frontal Cortex (r = 0.61) and FC of Left Thalamus to left Putamen, Pallidum, Caudate, Thalamus Hippocampus and Insula (r 0.55) showed a positive correlation to the duration of the longest seizure. The findings of the current study report altered connectivity in children with CFS proportional to the seizure recurrence and duration. Regardless of the causal/consequential nature, such observations demonstrate the imprint of these disease-defining variables of febrile seizures on the developing brain.
复杂热性惊厥（CFS）是儿科热性惊厥（FS）的一个子集，其预后、致痫潜能和神经认知结局已得到研究。我们评估了它们与近期 FS 儿童单纯热性惊厥（SFS）之间的功能连接差异。对 24 名近期诊断为 FS 的儿童（SFS-n=11；CFS-n=13）的静息态 fMRI(rs-fMRI)数据集进行了分析。使用种子区域到全脑体素的时间序列相关性估计功能连接（FC），并使用图论测量评估网络拓扑。对区域连接差异与临床特征进行相关性分析（FDR 校正 p<0.05）。与 SFS 相比，CFS 患者双侧颞中回（MTP）和双侧丘脑的 FC 增加。网络拓扑研究显示基底节和丘脑的聚类系数增加，参与系数降低，表明 CFS 患者的网络拓扑效率不平衡。癫痫发作复发次数与左丘脑的整合（r=-0.58）和左 MTP 与“右辅助运动区和左中央前回”的 FC（r=-0.53）呈负相关。右 MTP 与左杏仁核、壳核、海马旁回和眶额皮质的 FC（r=0.61）和左丘脑与左壳核、苍白球、尾状核、丘脑、海马和岛叶的 FC（r=0.55）呈正相关与最长发作持续时间有关。本研究的结果报告了 CFS 儿童的连接改变与癫痫发作的复发和持续时间成正比。无论因果关系如何，这些观察结果都表明热性惊厥的这些疾病定义变量对发育中大脑的影响。
