College of Plant Protection, Northwest A&F University, Xian Yang Shi, Yangling, 712100, P.R. China.
Chemistry. 2024 Jan 16;30(4):e202302595. doi: 10.1002/chem.202302595. Epub 2023 Nov 14.
Podophyllotoxin is an aryltetralin lignan lactone derived from different plants of Podophyllum. It consists of five rings with four chiral centers, one trans-lactone and one aryl tetrahydronaphthalene skeleton with multiple modification sites. Moreover, podophyllotoxin and its derivatives showed lots of bioactivities, including anticancer, anti-inflammatory, antiviral, and insecticidal properties. The demand for podophyllotoxin and its derivatives is rising as a result of their high efficacy. As a continuation of our previous review (Chem. Eur. J., 2017, 23, 4467-4526), herein, total synthesis, biotransformation, structural modifications, bioactivities, and structure-activity relationships of podophyllotoxin and its derivatives from 2017 to 2022 are summarized. Meanwhile, a piece of update information on the origin of new podophyllotoxin analogues from plants from 2014 to 2022 was compiled. We hope that this review will provide a reference for future high value-added applications of podophyllotoxin and its analogues in the pharmaceutical and agricultural fields.
鬼臼毒素是一种芳基四氢萘类木脂素内酯，来源于不同的鬼臼属植物。它由五个环组成，有四个手性中心，一个反式内酯和一个芳基四氢萘骨架，具有多个修饰位点。此外，鬼臼毒素及其衍生物具有多种生物活性，包括抗癌、抗炎、抗病毒和杀虫特性。由于其高效，鬼臼毒素及其衍生物的需求正在上升。作为我们之前综述（Chem. Eur. J.，2017，23，4467-4526）的延续，本文综述了 2017 年至 2022 年鬼臼毒素及其衍生物的全合成、生物转化、结构修饰、生物活性和构效关系。同时，还对 2014 年至 2022 年植物中新鬼臼毒素类似物的来源进行了更新信息的汇编。我们希望这篇综述能为未来鬼臼毒素及其类似物在医药和农业领域的高附加值应用提供参考。
