Department of Urology, The First Affiliated Hospital of Bengbu Medical College, No.287, Changhuai Road, 233040, Anhui, Bengbu, Longzihu, Bengbu, China.
The Central Laboratory of the First Affiliated Hospital of Bengbu Medical College, Anhui, Bengbu, 233040, China.
BMC Cancer. 2023 Oct 9;23(1):956. doi: 10.1186/s12885-023-11175-9.
MicroRNAs (miRNAs) have been reported to serve as potential biomarkers in bladder cancer and play important roles in cancer progression. This study aimed to investigate the biological role of miR-205-3p in bladder cancer. We showed that miR-205-3p was significantly down-regulated in bladder cancer tissues and cells. Moreover, overexpression of miR-205-3p inhibited bladder cancer progression in vitro. Then we confirmed that GLO1, a downstream target of miR-205-3p, mediated the effect of miR-205-3p on bladder cancer cells. In addition, we found that miR-205-3p inhibits P38/ERK activation through repressing GLO1. Eventually, we confirmed that miR-205-3p inhibits the occurrence and progress of bladder cancer by targeting GLO1 in vivo by nude mouse tumorigenesis and immunohistochemistry. In a word, miR-205-3p inhibits proliferation and metastasis of bladder cancer cells by activating the GLO1 mediated P38/ERK signaling pathway and that may be a potential therapeutic target for bladder cancer.
MicroRNAs (miRNAs) 已被报道可作为膀胱癌的潜在生物标志物，并在癌症进展中发挥重要作用。本研究旨在探讨 miR-205-3p 在膀胱癌中的生物学作用。我们发现 miR-205-3p 在膀胱癌组织和细胞中显著下调。此外，过表达 miR-205-3p 可抑制膀胱癌的体外进展。然后我们证实 GLO1 是 miR-205-3p 的下游靶标，介导了 miR-205-3p 对膀胱癌细胞的作用。此外，我们发现 miR-205-3p 通过抑制 GLO1 来抑制 P38/ERK 的激活。最终，我们通过裸鼠肿瘤生成和免疫组织化学证实，miR-205-3p 通过靶向 GLO1 抑制体内膀胱癌的发生和进展。总之，miR-205-3p 通过激活 GLO1 介导的 P38/ERK 信号通路抑制膀胱癌细胞的增殖和转移，这可能是膀胱癌的潜在治疗靶点。
