Core Laboratory of Glycobiology and Glycoengineering, College of Basic Medical Sciences, Dalian Medical University, Dalian, China.
Department of Gynecology, First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China.
J Pineal Res. 2024 Jan;76(1):e12918. doi: 10.1111/jpi.12918. Epub 2023 Oct 9.
Endometrial cancer (EC) is a reproductive system disease that occurs in perimenopausal and postmenopausal women. However, its etiology is unclear. Melatonin (MT) has been identified as a therapeutic agent for EC; however, its exact mechanism remains unclear. In the present study, we determined that GATA-binding protein 2 (GATA2) is expressed at low levels in EC and regulated by MT. MT upregulates the expression of GATA2 through MT receptor 1A (MTNR1A), whereas GATA2 can promote the expression of MTNR1A by binding to its promoter region. In addition, in vivo and in vitro experiments showed that MT inhibited the proliferation and metastasis of EC cells by upregulating GATA2 expression. The protein kinase B (AKT) pathway was also affected. In conclusion, these findings suggest that MT and GATA2 play significant roles in EC development.
子宫内膜癌（EC）是一种发生在围绝经期和绝经后妇女的生殖系统疾病。然而，其病因尚不清楚。褪黑素（MT）已被确定为 EC 的治疗药物；然而，其确切机制尚不清楚。在本研究中，我们确定 GATA 结合蛋白 2（GATA2）在 EC 中低表达，并受 MT 调节。MT 通过 MT 受体 1A（MTNR1A）上调 GATA2 的表达，而 GATA2 可以通过结合其启动子区域促进 MTNR1A 的表达。此外，体内和体外实验表明，MT 通过上调 GATA2 的表达抑制 EC 细胞的增殖和转移。蛋白激酶 B（AKT）通路也受到影响。总之，这些发现表明 MT 和 GATA2 在 EC 的发展中起重要作用。
