Vlassara H, Spiegel R J, San Doval D, Cerami A
Horm Metab Res. 1986 Oct;18(10):698-703. doi: 10.1055/s-2007-1012410.
Post-heparin plasma lipoprotein lipase activity was measured in 28 cancer patients with varying degrees of weight loss, and in 16 normal volunteers. Total lipoprotein lipase activity was decreased by 35.4% (P less than 0.001) in the cancer group. The component lipase activities, hepatic (HLPL), and peripheral (PLPL), were decreased by 40% (P less than 0.001) and 38% (P less than 0.005) respectively. In addition, the level of total peripheral lipoprotein lipase correlated well with the percent body weight lost by these patients (r = 0.6, P less than 0.01). Regardless of extent of disease, patients with lung cancer showed the lowest enzyme activity (mean 191 mU/ml +/- 30 SEM, P less than 0.001) and the greatest percent of weight loss (mean 16%), while patients with breast cancer had nearly normal lipase activity (mean 315 mU/ml +/- 50 SEM, normal 340 mU/ml +/- 22 SEM, P less than 0.10) and minimal weight loss (mean 8.4%). Fasting serum triglycerides were significantly elevated in the patient group (mean 120 mg/dl +/- 9.7 SEM) as compared to normal (mean 71 mg/dl +/- 7 SEM, P less than 0.001). The mean fasting insulin level was elevated in the patient group (13 mU/ml +/- 3.0 SEM), although in the majority of the patients it was found within the normal range (4-24 mU/ml). We conclude that the significant decrease in the total LPL activity may be responsible in part for the characteristic hypertriglyceridemia present in cancer patients.
对28例体重减轻程度不同的癌症患者以及16名正常志愿者测定了肝素后血浆脂蛋白脂肪酶活性。癌症组的总脂蛋白脂肪酶活性降低了35.4%（P<0.001）。其组成部分脂肪酶活性，即肝型（HLPL）和外周型（PLPL），分别降低了40%（P<0.001）和38%（P<0.005）。此外，外周总脂蛋白脂肪酶水平与这些患者体重减轻的百分比密切相关（r = 0.6，P<0.01）。无论疾病程度如何，肺癌患者的酶活性最低（平均191 mU/ml±30 SEM，P<0.001），体重减轻百分比最大（平均16%），而乳腺癌患者的脂肪酶活性接近正常（平均315 mU/ml±50 SEM，正常为340 mU/ml±22 SEM，P<0.10），体重减轻最少（平均8.4%）。与正常组（平均71 mg/dl±7 SEM，P<0.001）相比，患者组的空腹血清甘油三酯显著升高（平均120 mg/dl±9.7 SEM）。患者组的平均空腹胰岛素水平升高（13 mU/ml±3.0 SEM），尽管大多数患者的胰岛素水平在正常范围内（4 - 24 mU/ml）。我们得出结论，总LPL活性的显著降低可能部分导致了癌症患者特有的高甘油三酯血症。
