Jungmann E, Schwedes U, Althoff P H, Rosak C, Schöffling K
Horm Metab Res. 1986 Oct;18(10):704-5. doi: 10.1055/s-2007-1012411.
Aldosterone responsiveness to consecutive i.v. injections of metoclopramide 1 mg, 2.5 mg and 10 mg was studied in 8 patients with prolactinoma and normally preserved adrenal function and in 14 healthy volunteers. In the patients, aldosterone response to metoclopramide 1 mg was blunted. After metoclopramide 10 mg, aldosterone rose to the same levels in patients and volunteers. In the patients, however, percentage rise of aldosterone was enhanced, since the appropriate base line concentration of aldosterone was decreased. Thus, there is evidence for increased endogenous dopaminergic inhibition of aldosterone secretion in prolactinoma.
对8例患有泌乳素瘤且肾上腺功能正常的患者以及14名健康志愿者，研究了醛固酮对连续静脉注射1毫克、2.5毫克和10毫克胃复安的反应。在这些患者中，醛固酮对1毫克胃复安的反应减弱。在注射10毫克胃复安后，患者和志愿者的醛固酮水平升至相同高度。然而，在患者中，醛固酮的升高百分比增加，因为醛固酮的适当基线浓度降低。因此，有证据表明泌乳素瘤中内源性多巴胺能对醛固酮分泌的抑制作用增强。
