Borja Montes Oscar F, Escobar Gil Tomas, Cardona Solano Camilo, Padilla Daniel
Internal Medicine, University of New Mexico School of Medicine, Albuquerque, USA.
Internal Medicine, Universidad Libre, Cali, COL.
Cureus. 2023 Sep 8;15(9):e44907. doi: 10.7759/cureus.44907. eCollection 2023 Sep.
Leser-Trélat syndrome, a rare cutaneous paraneoplastic phenomenon, has gained attention for its potential role as an early indicator of underlying internal malignancies. This article presents a comprehensive case study of a 67-year-old male with a history of alcohol and tobacco use, emphasizing the importance of recognizing this syndrome in clinical practice. The sudden onset of seborrheic keratoses on the thorax and back, retrospectively identified as Leser-Trélat syndrome, prompted investigations that led to the early diagnosis of a colon adenocarcinoma. We discuss the pathophysiology, clinical relevance, and controversies surrounding this syndrome, highlighting the need for increased awareness among healthcare professionals. Timely recognition of Leser-Trélat syndrome can significantly impact patient care, leading to improved prognoses for associated neoplasms. This case underscores the importance of comprehensive evaluations and further research to enhance our understanding and management of cutaneous paraneoplastic syndromes.
勒泽-特雷拉综合征是一种罕见的皮肤副肿瘤现象，因其作为潜在内部恶性肿瘤早期指标的作用而受到关注。本文介绍了一名有酗酒和吸烟史的67岁男性的综合病例研究，强调了在临床实践中认识该综合征的重要性。胸部和背部突然出现脂溢性角化病，回顾性诊断为勒泽-特雷拉综合征，促使进行了相关检查，从而早期诊断出结肠腺癌。我们讨论了该综合征的病理生理学、临床相关性及相关争议，强调了提高医疗专业人员认识的必要性。及时识别勒泽-特雷拉综合征可显著影响患者护理，改善相关肿瘤的预后。该病例强调了全面评估和进一步研究的重要性，以增进我们对皮肤副肿瘤综合征的理解和管理。
