鞣花酸通过调节老年大鼠的SIRT1和AMPK来降低肝脏脂质含量。
Ellagic acid reduces hepatic lipid contents through regulation of SIRT1 and AMPK in old rats.
作者信息
Rahimi Naiini Mahdis, Shahouzehi Beydolah, Khaksari Mohammad, Azizi Shahrzad, Naghibi Niloufar, Nazari-Robati Mahdieh
机构信息
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
Arch Physiol Biochem. 2024 Dec;130(6):686-693. doi: 10.1080/13813455.2023.2262165. Epub 2023 Oct 10.
OBJECTIVE
Ellagic acid is used in traditional medicine for the treatment of lipid disorders. In this study, the effects of ellagic acid on key regulators of lipid metabolism, and histopathological alterations in aged liver were examined.
METHODS
A total of 21 male Wistar rats were divided into three groups, including young control, old control, and old ellagic acid. After one month of treatment with ellagic acid, the expression levels of hepatic SIRT1, AMPK, SREBP-1c, PPAR-α, and phosphorylated AMPK (p-AMPK) were evaluated. The levels of several serum biochemical factors, and hepatic triglyceride, and cholesterol contents were assessed.
RESULTS
Ellagic acid elevated the levels of SIRT1, p-AMPK, and PPAR-α and reduced SREBP-1c level in the liver of old rats. It decreased triglyceride and cholesterol contents in the aged liver and improved histopathological changes.
CONCLUSIONS
The results demonstrated that ellagic acid can exert protective effects against hepatic lipid metabolism disorders induced by ageing.
目的
鞣花酸在传统医学中用于治疗脂质紊乱。在本研究中，研究了鞣花酸对脂质代谢关键调节因子的影响以及对老龄肝脏组织病理学改变的影响。
方法
将总共21只雄性Wistar大鼠分为三组，包括年轻对照组、老龄对照组和老龄鞣花酸组。在用鞣花酸治疗一个月后，评估肝脏中SIRT1、AMPK、SREBP-1c、PPAR-α和磷酸化AMPK（p-AMPK）的表达水平。评估了几种血清生化因子水平以及肝脏甘油三酯和胆固醇含量。
结果
鞣花酸提高了老龄大鼠肝脏中SIRT1、p-AMPK和PPAR-α的水平，并降低了SREBP-1c水平。它降低了老龄肝脏中的甘油三酯和胆固醇含量，并改善了组织病理学变化。
结论
结果表明，鞣花酸可对衰老诱导的肝脏脂质代谢紊乱发挥保护作用。
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