School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Nutrilite Health Institute, Amway (Shanghai) Innovation and Science Co., Ltd., Shanghai 201203, China.
Nutrients. 2024 Sep 29;16(19):3305. doi: 10.3390/nu16193305.
Aging is a natural biological process influenced by multiple factors and is a significant contributor to various chronic diseases. Slowing down the aging process and extending health span have been pursuits of the scientific field. Examination of the effects of dietary polyphenols on hallmarks of aging such as genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered intercellular communication, chronic inflammation, and dysbiosis. Polyphenols, abundant in nature, exhibit numerous biological activities, including antioxidant effects, free radical scavenging, neuroprotection, and anti-aging properties. These compounds are generally safe and effective in potentially slowing aging and preventing age-related disorders. The review encourages the development of novel therapeutic strategies using dietary polyphenols to create holistic anti-aging therapies and nutritional supplements.
衰老是一个受多种因素影响的自然生物学过程，也是各种慢性疾病的重要诱因。减缓衰老过程并延长健康寿命一直是科学领域的追求。研究饮食中的多酚类化合物对衰老标志的影响，如基因组不稳定性、端粒磨损、表观遗传改变、蛋白质稳态丧失、大自噬功能障碍、营养感应失调、线粒体功能障碍、细胞衰老、干细胞衰竭、细胞间通讯改变、慢性炎症和菌群失调。多酚类化合物在自然界中含量丰富，具有多种生物学活性，包括抗氧化作用、清除自由基、神经保护和抗衰老特性。这些化合物通常安全有效，有可能减缓衰老并预防与年龄相关的疾病。该综述鼓励使用饮食中的多酚类化合物开发新的治疗策略，以创造整体抗衰老疗法和营养补充剂。
