Unit of Otorhinolaryngology - Head and Neck Surgery, ASST Spedali Civili of Brescia, Brescia, Italy.
Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, School of Medicine, Brescia, Italy.
Acta Otorhinolaryngol Ital. 2023 Dec;43(6):365-374. doi: 10.14639/0392-100X-N2635. Epub 2023 Oct 10.
Malignant minor salivary glands carcinomas (MiSGC) of the larynx and trachea are rare tumours and published evidence is sparse. We conducted a systematic review to describe shareable treatment strategies and oncological outcomes of these neoplastic entities.
Full text English manuscripts published from January 1 2000 to December 14 2022 were included. Data on demographics, treatments and outcomes were collected. A pooled analysis of 5-year overall survival (OS) was performed.
Seventeen articles and 365 patients met the inclusion criteria. The most common subsites involved were subglottic and distal trachea. Adenoid cystic carcinoma was, by far, the most frequent histotype. The first-choice treatment strategy was surgery (86.8%), while adjuvant treatments were delivered in 57.4% of patients. Only 12.9% were treated with definitive radiotherapy with/without chemotherapy. The mean follow-up was 68.3 months. One hundred nine (34.9%) deaths were recorded and 62.4% were cancer-related. Five-year OS ranged from 20% to 100% and, at pooled analysis, it was 83% (range, 78-87%).
In case of MiSGC of the larynx and trachea, surgery remains the mainstay of treatment. Adjuvant treatments are frequently delivered. Survival estimates are good overall, but highly heterogeneous.
喉和气管的恶性小涎腺癌（MiSGC）是罕见的肿瘤，且已有文献证据有限。我们进行了一项系统评价，以描述这些肿瘤实体的可分享治疗策略和肿瘤学结果。
纳入 2000 年 1 月 1 日至 2022 年 12 月 14 日发表的全文为英文的文献。收集了有关人口统计学、治疗和结局的数据。对 5 年总生存率（OS）进行了汇总分析。
17 篇文章和 365 例患者符合纳入标准。最常见的部位是声门下和远端气管。腺样囊性癌是迄今为止最常见的组织类型。首选的治疗策略是手术（86.8%），而 57.4%的患者接受了辅助治疗。仅有 12.9%的患者接受了根治性放化疗。平均随访时间为 68.3 个月。记录了 109 例（34.9%）死亡，其中 62.4%与癌症相关。5 年 OS 从 20%到 100%不等，汇总分析为 83%（范围为 78-87%）。
对于喉和气管的 MiSGC，手术仍然是主要的治疗方法。辅助治疗常被应用。总体生存估计良好，但高度异质性。
