Yilgör Abdullah, Kurhan Faruk
Faculty of Medicine, Department of Neurology, Van Yuzuncu Yil University, Turkey.
Faculty of Medicine, Department of Psychiatry, Van Yuzuncu Yil University, Turkey.
J Interpers Violence. 2024 Mar;39(5-6):1228-1244. doi: 10.1177/08862605231203964. Epub 2023 Oct 10.
Childhood traumas have been considered risk factors for many psychiatric disorders. Recent studies demonstrated that childhood traumas can also be considered risk factors for neurological diseases. In this context, the objective of this study is to investigate the effects of childhood traumas on treatment resistance in patients with epilepsy. The study sample consisted of 85 epilepsy patients, 40 male and 45 female, who were diagnosed and followed up by a neurologist. Of these patients, 45 were being followed up with the diagnosis of refractory epilepsy, and 40 were being followed up with the diagnosis of treatment-responsive epilepsy. Cranial magnetic resonance imaging and electroencephalography were performed on all patients. In addition, all patients were administered childhood trauma questionnaire (CTQ) and Hamilton depression rating scale (HAM-D). Epilepsy patients included in the study were divided into refractory epilepsy and treatment-responsive epilepsy groups. There was no significant difference between the groups in sociodemographic characteristics. On the other hand, total CTQ and all CTQ subscale scores and HAM-D scores were significantly higher in the refractory epilepsy group than in the treatment-responsive epilepsy group. This study demonstrates that childhood traumas may contribute to treatment resistance in epilepsy patients. Therefore, it is recommended that a history of childhood traumas be routinely queried in the treatment of epilepsy patients.
童年创伤一直被认为是许多精神疾病的危险因素。最近的研究表明，童年创伤也可被视为神经疾病的危险因素。在此背景下，本研究的目的是调查童年创伤对癫痫患者治疗抵抗性的影响。研究样本包括85名癫痫患者，其中男性40名，女性45名，由神经科医生进行诊断和随访。在这些患者中，45名被诊断为难治性癫痫并接受随访，40名被诊断为对治疗有反应的癫痫并接受随访。对所有患者进行了头颅磁共振成像和脑电图检查。此外，所有患者均接受了童年创伤问卷（CTQ）和汉密尔顿抑郁量表（HAM-D）测试。纳入研究的癫痫患者被分为难治性癫痫组和对治疗有反应的癫痫组。两组在社会人口学特征方面无显著差异。另一方面，难治性癫痫组的CTQ总分、所有CTQ子量表得分和HAM-D得分均显著高于对治疗有反应的癫痫组。本研究表明，童年创伤可能导致癫痫患者产生治疗抵抗性。因此，建议在癫痫患者的治疗中常规询问童年创伤史。
