Xia Jingxuan, Zhang Zhiyuan, Huang Yijin, Wang Yufei, Liu Guangwei
Key Laboratory of Cell Proliferation and Regulation Biology, Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing, China.
Int J Cancer. 2024 Mar 1;154(5):773-785. doi: 10.1002/ijc.34750. Epub 2023 Oct 10.
Neutrophil extracellular trap (NET) is one of the defense functions of neutrophils, which has a rapid ability to kill infections and is also crucial in a variety of immune-associated diseases including infections, tumors and autoimmune diseases. Recent studies have shown that NETs are closely related to the development of tumors. The regulatory role of NETs in tumors has been of interest to researchers. In addition to awakening latent tumor cells, NETs can also promote the proliferation and development of tumor cells and their metastasis to other sites. At the same time, NETs also have the effect of inhibiting tumors. At present, there are some new advances in the impact of NETs on tumor development, which will provide a more theoretical basis for developing NET-targeted drugs. Therefore, this review just summarized the formation process of NETs, the regulation of tumor development and the treatment methods based on NETs.
中性粒细胞胞外陷阱（NET）是中性粒细胞的防御功能之一，具有快速杀灭感染的能力，在包括感染、肿瘤和自身免疫性疾病在内的多种免疫相关疾病中也起着关键作用。最近的研究表明，NET与肿瘤的发生发展密切相关。NET在肿瘤中的调节作用一直是研究人员关注的焦点。除了唤醒潜伏的肿瘤细胞外，NET还可以促进肿瘤细胞的增殖、发展及其向其他部位的转移。同时，NET也具有抑制肿瘤的作用。目前，NET对肿瘤发展的影响有了一些新进展，这将为开发针对NET的药物提供更多的理论依据。因此，本综述仅总结了NET的形成过程、对肿瘤发展的调节作用以及基于NET的治疗方法。
