Yadav Agrima, Yadav Shikha, Alam Md Aftab
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh, India.
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Plot No. 2, Sector 17-A, Yamuna Expressway, Gautam Buddh Nagar, Greater Noida, Uttar Pradesh, 201310, India.
Med Oncol. 2023 Oct 10;40(11):328. doi: 10.1007/s12032-023-02188-2.
Cervical cancer ranks as the fourth most common form of cancer worldwide. There is a large number of situations that may be examined in the developing world. The risk of contracting HPV (Human Papillomavirus) due to poor sanitation and sexual activity is mostly to blame for the disease's alarming rate of expansion. Immunotherapy is widely regarded as one of the most effective medicines available. The immunotherapy used to treat cervical cancer cells relies on inhibitors that block the immune checkpoint. The poly adenosine diphosphate ribose polymer inhibited cervical cancer cells by activating both the programmed death 1 (PD-1) and programmed death ligand 1 (CTLA-1) checkpoints, a strategy that has been shown to have impressive effects. Yet, immunotherapy directed towards tumors that have already been invaded by lymphocytes leaves a positive imprint on the healing process. Immunotherapy is used in conjunction with other treatments, including chemotherapy and radiation, to provide faster and more effective outcomes. In this combination therapy, several medications such as Pembrolizumab, Durvalumab, Atezolizumab, and so on are employed in clinical trials. Recent developments and future predictions suggest that vaccinations will soon be developed with the dual goal of reducing the patient's susceptibility to illness while simultaneously strengthening their immune system. Many clinical and preclinical studies are now investigating the effectiveness of immunotherapy in slowing the progression of cervical cancer. The field of immunotherapy is expected to witness more progress toward improving outcomes. Immunotherapies landscape and associated inhibitors for the treatment of Cervical Cancer.
宫颈癌是全球第四大常见癌症。在发展中国家,有大量情况可能需要进行检查。由于卫生条件差和性行为导致感染人乳头瘤病毒(HPV)的风险,在很大程度上是该疾病惊人扩张速度的罪魁祸首。免疫疗法被广泛认为是现有的最有效药物之一。用于治疗宫颈癌细胞的免疫疗法依赖于阻断免疫检查点的抑制剂。聚腺苷二磷酸核糖聚合酶通过激活程序性死亡1(PD - 1)和程序性死亡配体1(CTLA - 1)检查点来抑制宫颈癌细胞,这一策略已显示出令人印象深刻的效果。然而,针对已经被淋巴细胞侵袭的肿瘤的免疫疗法在愈合过程中留下了积极的印记。免疫疗法与其他治疗方法(包括化疗和放疗)联合使用,以提供更快、更有效的治疗效果。在这种联合治疗中,几种药物如帕博利珠单抗、度伐利尤单抗、阿替利珠单抗等正在临床试验中使用。最近的进展和未来预测表明,很快将开发出具有双重目标的疫苗,即降低患者对疾病的易感性,同时增强他们的免疫系统。许多临床和临床前研究正在调查免疫疗法在减缓宫颈癌进展方面的有效性。免疫疗法领域有望在改善治疗效果方面取得更多进展。宫颈癌治疗的免疫疗法格局及相关抑制剂