Ryan C J, Courtney J M, Aslam M, Falkenhagen D, Böttcher M, Klinkmann H
Int J Artif Organs. 1986 Sep;9(5):293-6.
The selection of assessment procedures for the preclinical evaluation of haemosorbents and the relationship between such procedures and the intended application are exemplified by examination of the design and utilization of procedures based on the rat. Procedures are described for haemoperfusion and for membrane plasma separation followed by on-line sorbent treatment of plasma (plasma perfusion). These procedures are suitable for single or repeated use, with the animal in an unrestrained and conscious state. The relevance to the intended application is demonstrated with respect to artificial liver support by the ability of rat extracorporeal circuits to provide information on the relationship between sorbent properties and liver regeneration as determined by the proliferative response following partial hepatectomy.
通过对基于大鼠的评估程序的设计和应用进行考察，举例说明了血液吸附剂临床前评估中评估程序的选择以及这些程序与预期应用之间的关系。文中描述了血液灌流以及膜血浆分离后对血浆进行在线吸附剂处理（血浆灌注）的程序。这些程序适用于单次或重复使用，动物处于不受约束的清醒状态。通过大鼠体外循环能够提供有关吸附剂特性与肝再生之间关系的信息（这种关系由部分肝切除后的增殖反应确定），证明了其与人工肝支持预期应用的相关性。
