Odaka M, Kobayashi H, Soeda K, Murotani N, Saito Y, Nishide T, Yoshida S, Tani N, Takata S
Int J Artif Organs. 1986 Sep;9(5):343-8.
For the treatment of familial hypercholesterolemia, Liposorber LA-40 was clinically applied. The Liposorber is a commercially developed affinity adsorbent for plasma perfusion which selectivity adsorbs low density lipoproteins and very low density lipoproteins and is specially designed for plasmapheretic treatment of hypercholesterolemia. The Liposorber column, containing activated cellulose beads having an affinity for lipoprotein containing apolipoprotein-B, has an excellent adsorption capacity, excellent selectivity, minimum albumin loss. This new apheresis system was applied to 2 clinical cases. After seven months of trial perfusion every 2 weeks, patient condition was good, with a level of total cholesterol under 300 mg/dl. No replacement fluids were given during or after treatment. In this paper, clinical results of these patients were shown and the mechanism of adsorption of this specific adsorbent was discussed.
为治疗家族性高胆固醇血症，临床应用了脂质吸附器LA - 40。脂质吸附器是一种商业开发的用于血浆灌注的亲和吸附剂，它能选择性吸附低密度脂蛋白和极低密度脂蛋白，是专门为血浆置换治疗高胆固醇血症而设计的。脂质吸附柱含有对含载脂蛋白B的脂蛋白具有亲和力的活化纤维素珠，具有出色的吸附能力、良好的选择性以及最小的白蛋白损失。这种新的血液分离系统应用于2例临床病例。每2周进行一次为期7个月的试验性灌注后，患者状况良好，总胆固醇水平低于300mg/dl。治疗期间及治疗后均未给予置换液。本文展示了这些患者的临床结果，并讨论了这种特定吸附剂的吸附机制。
