Carroll Adam M, King R Wilson, Ghincea Christian V, Aftab Muhammad, Reece T Brett
Division of Cardiothoracic Surgery, Department of Surgery, Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, CO, USA.
Ann Cardiothorac Surg. 2023 Sep 28;12(5):438-449. doi: 10.21037/acs-2023-scp-08. Epub 2023 May 15.
This keynote lecture and corresponding presentation discuss the anatomy and pathophysiology surrounding spinal cord injury in aortic surgery. This article will discuss risk factors and mechanisms for spinal cord injury, including loss of direct and collateral spinal cord perfusion and ischemia-reperfusion injury. This review will examine these elements in both the laboratory and clinical setting, in addition to other neuroprotective strategies applied in clinical practice. Addressing spinal cord injury requires an integrated and considerate approach to simultaneously optimize spinal cord blood flow, promote collateralization and improve ischemic tolerance. Given the catastrophic clinical consequences for both the patient and their caregivers, continuing to investigate and examine spinal cord injury is of the utmost importance.
本次主题演讲及相应演示讨论了主动脉手术中脊髓损伤的解剖学和病理生理学。本文将讨论脊髓损伤的危险因素和机制，包括脊髓直接和间接灌注丧失以及缺血再灌注损伤。本综述将在实验室和临床环境中研究这些因素，以及临床实践中应用的其他神经保护策略。解决脊髓损伤问题需要一种综合且周全的方法，以同时优化脊髓血流、促进侧支循环并提高缺血耐受性。鉴于脊髓损伤对患者及其护理人员都会带来灾难性的临床后果，持续研究和探讨脊髓损伤至关重要。
