Gebretensaie Yosef, Atnafu Abay, Alemu Yonas, Girma Selfu, Desta Kassu
American Advanced Medical Laboratory, American Medical Center, Addis Ababa, Ethiopia.
Armauer Hansen Research Institute, Addis Ababa, Ethiopia.
Res Rep Urol. 2023 Oct 4;15:437-445. doi: 10.2147/RRU.S434128. eCollection 2023.
Urinary tract infections (UTIs) bring a significant and serious health-related problem. Repeated infections may lead to the development of renal scarring and end-stage renal dysfunction. Therefore, balancing the choices of UTI diagnostic tools depending on the costs versus accuracy can minimize false results that may subject patients to wrong treatments.
The objective of the study was to evaluate the diagnostic performance of LINEAR cromatest and Laboquick URS 10-T dipsticks against conventional urine culture at Arsho Advanced Medical Laboratory (AAML), Addis Ababa, Ethiopia.
A similar cohort of UTI-suspected patients from our previous study, who were prospectively enrolled from Arsho Advanced Medical Laboratory, Addis Ababa, Ethiopia, were considered for this analysis. Data analysis was performed using SPSS version 26. The sensitivity, specificity, and predictive value of different dipsticks were calculated using culture as a gold standard. ROC curve analysis was also used to determine diagnostic performance. A test with a P-value of <0.05 was considered statistically significant.
Out of 446 urine samples processed, bacterial growth was observed in 141 (31.6%). Of this figure, 105/141 (74.5%) and 36/141 (25.5%) were from female and male participants, respectively. The sensitivity and specificity of the LINEAR Cromatest dipstick were 83.7% and 67.9%, respectively (-value <0.001). The Laboquick URS 10-T dipstick showed sensitivity and specificity of 87.9% and 68.5%, respectively (-value <0.001). The ROC analysis showed an AUC of >0.7 for both dipsticks.
In a setting where there is no access to urine culture, the urine dipstick may be considered an alternative diagnostic tool in the diagnosis of UTIs.
尿路感染（UTIs）带来了一个重大且严重的健康相关问题。反复感染可能导致肾瘢痕形成和终末期肾功能障碍。因此，根据成本与准确性平衡尿路感染诊断工具的选择，可以最大限度地减少可能使患者接受错误治疗的假结果。
本研究的目的是在埃塞俄比亚亚的斯亚贝巴的阿尔绍高级医学实验室（AAML）评估线性克罗马测试条和Laboquick URS 10 - T试纸相对于传统尿培养的诊断性能。
对我们之前研究中来自埃塞俄比亚亚的斯亚贝巴阿尔绍高级医学实验室的一组疑似尿路感染患者进行前瞻性招募，纳入本分析。使用SPSS 26版进行数据分析。以培养作为金标准计算不同试纸的敏感性、特异性和预测值。还使用ROC曲线分析来确定诊断性能。P值<0.05的测试被认为具有统计学意义。
在处理的446份尿液样本中，观察到141份（31.6%）有细菌生长。其中，105/141（74.5%）和36/141（25.5%）分别来自女性和男性参与者。线性克罗马测试条的敏感性和特异性分别为83.7%和67.9%（P值<0.001）。Laboquick URS 10 - T试纸的敏感性和特异性分别为87.9%和68.5%（P值<0.001）。ROC分析显示两种试纸的AUC均>0.7。
在无法进行尿培养的情况下，尿试纸可被视为诊断尿路感染的替代诊断工具。
