Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang 37673, Republic of Korea.
Innovation Lab. Cosmax R&I Center, Seongnam 13486, Republic of Korea.
Biomater Sci. 2023 Nov 21;11(23):7531-7540. doi: 10.1039/d3bm01411h.
The barrier function of the skin in effectively protecting the underlying tissue from the surrounding environment makes it challenging to achieve the efficient transdermal delivery of actives. Herein, we report on alcohol-solvent-encapsulated microcapsules to achieve enhanced skin efficacy. We show that using palm oil as the shell material allows for the microencapsulation of a broad range of alcohol solvents, including ethanol and dipropylene glycol (DPG), as well as on-demand release. Moreover, clinical trials reveal that the high-content actives in microcapsules result in enhanced skin efficacy, and the presence of DPG effectively mediates the transdermal delivery of these actives without causing any skin irritation. We envision that the alcohol-solvent microencapsulation strategy outlined in this work offers new possibilities in cosmetics, food, and drug delivery systems.
皮肤的屏障功能有效地将底层组织与周围环境隔离开来，这使得活性物质的经皮传递变得极具挑战性。在此，我们报告了一种利用醇溶剂包封微胶囊来提高皮肤功效的方法。我们发现，使用棕榈油作为壳材料可以实现广泛的醇溶剂（包括乙醇和二丙二醇（DPG））的微胶囊化，并实现按需释放。此外，临床试验表明，微胶囊中高含量的活性物质可提高皮肤功效，而 DPG 的存在可有效介导这些活性物质的经皮传递，而不会引起任何皮肤刺激。我们设想，本工作中概述的醇溶剂微胶囊化策略为化妆品、食品和药物输送系统提供了新的可能性。
