Soft Matter and Functional Interfaces Laboratory, Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongsangbuk-do 37673, South Korea.
Research and Innovation Center, Cosmax Inc., Seongnam, Gyeonggi-do 13486, South Korea.
ACS Appl Mater Interfaces. 2021 Aug 4;13(30):36380-36387. doi: 10.1021/acsami.1c04652. Epub 2021 Jul 13.
We present a microfluidic approach that utilizes temperature-responsive and biocompatible palm oil as the shell material in microcapsules to simultaneously achieve hermetic sealing as well as on-demand temperature-triggered release of the encapsulated actives. Unlike common paraffin waxes (e.g., eicosane), microcapsule shells comprising palm oil do not form pores or cracks during freezing and provide a hermetic seal, a nearly perfect seal that separates the core containing the actives from the surrounding environment over a prolonged period of time. This allows effective isolation and protection of complex cargoes such as small molecules with high diffusivity, strong acids, and cosmetic actives including niacinamide. Moreover, the palm oil shell melts above the defined melting temperature, allowing the on-demand release of the encapsulated actives. Furthermore, palm oil is biocompatible, is edible, and leaves a minimal footprint when used in personal care and cosmetic products, offering new perspectives in the design of microcapsules for cosmetic applications.
我们提出了一种微流控方法，该方法利用温度响应和生物相容的棕榈油作为微胶囊的壳材料，以同时实现密封以及封装活性物质的按需温度触发释放。与常见的石蜡（例如二十烷）不同，由棕榈油组成的微胶囊壳在冷冻过程中不会形成孔或裂缝，并提供密封，这种近乎完美的密封可将包含活性物质的核心与周围环境长时间隔离开来。这允许对复杂货物（例如具有高扩散性的小分子、强酸和包括烟酰胺在内的化妆品活性物质）进行有效隔离和保护。此外，棕榈油壳在定义的熔点以上熔化，从而允许按需释放封装的活性物质。此外，棕榈油具有生物相容性，可食用，并且在个人护理和化妆品产品中使用时留下的足迹很小，为化妆品应用中微胶囊的设计提供了新的视角。
