新型具有临床意义的尿失禁生活质量问卷（ICIQ-UI-SF）和 ICIQ-FLUTS 问卷评分在女性压力性尿失禁中的应用。
Novel clinically meaningful scores for the ICIQ-UI-SF and ICIQ-FLUTS questionnaires in women with stress incontinence.
机构信息
Department of Rehabilitation Science, Bangladesh Health Professions Institute (BHPI), Savar, Bangladesh.
Health Services Research Unit, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
出版信息
Int Urogynecol J. 2023 Dec;34(12):3033-3040. doi: 10.1007/s00192-023-05657-4. Epub 2023 Oct 11.
AIM
To establish, for the first time, the clinically important differences for the ICIQ-UI-SF and ICIQ-FLUTS questionnaires following surgical and conservative treatments for stress-predominant urinary incontinence in women.
METHODS
Data from the SIMS and OPAL randomised controlled trials were analysed using an anchor-based method. Clinically important difference (CID; score change indicating a successful outcome) and minimal important difference (MID; score change indicating the smallest noticeable difference) were estimated using the PGI-I scale as the anchor.
RESULTS
For ICIQ-UI-SF, following surgical management, CIDs were 5.0 (95%CI 4.3, 5.6) at 1 year and 4.9 points (95%CI 4.2, 5.5) at 3 years, while following conservative management, CIDs were 4.0 (95%CI 3.4, 4.5) at 1 year and 4.6 points (95%CI 4.0, 5.2) at 2 years. For ICIQ-FLUTS, the CID was 3.4 points (95%CI 2.9, 4.0) at 1 year for both surgical and conservative management. MIDs for ICIQ-UI-SF, after surgical treatment, were 4.7 (95% CI 3.2, 6.1) at 1 year and 1.6 points (95%CI -0.2, 3.0) at 3 years, and after conservative treatment they were 1.7 (95% CI 1.0, 2.5) at 1 year and 1.9 points (95%CI 1.1, 2.7) at 2 years. For ICIQ-FLUTS, MIDs were 1.8 (95% CI 0.6, 3.1) at 1 year and 3.2 points (95%CI 2.0, 4.4) at 2 years after surgical treatment, and 1.3 (95%CI 0.6, 1.9) at 1 year and 1.9 points (95%CI 1.1, 2.6) at 2 years after conservative treatment.
CONCLUSION
Our study is the first to establish the CID for the ICIQ-UI-SF and ICIQ-FLUTS that women would associate with a successful outcome 3-years post-surgery and 2-years post-conservative treatment of stress-predominant urinary incontinence. The MID was lower following conservative compared to surgical treatment.
目的
首次建立女性压力性尿失禁手术和保守治疗后，国际尿失禁咨询委员会尿失禁问卷简表（ICIQ-UI-SF）和国际尿失禁咨询委员会尿失禁问卷-短表（ICIQ-FLUTS）的临床重要差异。
方法
使用基于锚定的方法分析 SIMS 和 OPAL 随机对照试验的数据。使用患者总体印象改善（PGI-I）量表作为锚定物来估计临床重要差异（CID；表示治疗成功的评分变化）和最小重要差异（MID；表示可察觉的最小差异的评分变化）。
结果
对于 ICIQ-UI-SF，手术治疗后 1 年 CID 为 5.0（95%CI 4.3, 5.6），3 年 CID 为 4.9 分（95%CI 4.2, 5.5），而保守治疗后 1 年 CID 为 4.0（95%CI 3.4, 4.5），2 年 CID 为 4.6 分（95%CI 4.0, 5.2）。对于 ICIQ-FLUTS，手术和保守治疗后 1 年的 CID 均为 3.4 分（95%CI 2.9, 4.0）。ICIQ-UI-SF 术后治疗 1 年 MID 为 4.7（95%CI 3.2, 6.1），3 年 MID 为 1.6 分（95%CI -0.2, 3.0），而保守治疗后 1 年 MID 为 1.7（95%CI 1.0, 2.5），2 年 MID 为 1.9 分（95%CI 1.1, 2.7）。对于 ICIQ-FLUTS，手术治疗后 1 年 MID 为 1.8 分（95%CI 0.6, 3.1），2 年 MID 为 3.2 分（95%CI 2.0, 4.4），而保守治疗后 1 年 MID 为 1.3 分（95%CI 0.6, 1.9），2 年 MID 为 1.9 分（95%CI 1.1, 2.6）。
结论
本研究首次建立了女性压力性尿失禁术后 3 年和保守治疗后 2 年的 CID，认为这与治疗成功相关。与手术治疗相比，保守治疗后的 MID 更低。
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