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Linking ALS mutations to the disruption of the MHC-II pathway.

作者信息

Zhang Zhe, Sun Shuying

机构信息

Department of Physiology and Brain Science Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205.

出版信息

Proc Natl Acad Sci U S A. 2023 Oct 24;120(43):e2315240120. doi: 10.1073/pnas.2315240120. Epub 2023 Oct 11.

DOI:10.1073/pnas.2315240120
PMID:37819987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10614208/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367c/10614208/db5f31d69cde/pnas.2315240120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367c/10614208/db5f31d69cde/pnas.2315240120fig01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367c/10614208/db5f31d69cde/pnas.2315240120fig01.jpg

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Proc Natl Acad Sci U S A. 2023 Sep 26;120(39):e2305756120. doi: 10.1073/pnas.2305756120. Epub 2023 Sep 18.
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The contribution of the peripheral immune system to neurodegeneration.外周免疫系统对神经退行性变的贡献。
Nat Neurosci. 2023 Jun;26(6):942-954. doi: 10.1038/s41593-023-01323-6. Epub 2023 May 25.
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The role of inflammation in neurodegeneration: novel insights into the role of the immune system in C9orf72 HRE-mediated ALS/FTD.
炎症在神经退行性变中的作用:免疫系统在 C9orf72 HRE 介导的 ALS/FTD 中的作用的新见解。
Mol Neurodegener. 2022 Mar 18;17(1):22. doi: 10.1186/s13024-022-00525-z.
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Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72.C9ORF72 功能降低会加剧 ALS/FTD 致病重复扩展引起的毒性获得。
Nat Neurosci. 2020 May;23(5):615-624. doi: 10.1038/s41593-020-0619-5. Epub 2020 Apr 13.
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Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.相互作用组分析表明,U1 snRNP 机制与 RNAP II 机制广泛重叠,并包含多个 ALS/SMA 致病蛋白。
Sci Rep. 2018 Jun 8;8(1):8755. doi: 10.1038/s41598-018-27136-3.
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JAMA Neurol. 2017 Dec 1;74(12):1446-1454. doi: 10.1001/jamaneurol.2017.2255.
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