Department of Neurosurgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, PR China; Henan International Joint Laboratory of Glioma Metabolism and Microenvironment Research, Zhengzhou, Henan, PR China.
Department of Neurosurgery, Pituitary Adenoma Multidisciplinary Center, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.
Gene. 2024 Jan 20;892:147864. doi: 10.1016/j.gene.2023.147864. Epub 2023 Oct 10.
Cancer is a challenging issue for human health. One of the key methods to address this issue is by comprehending the molecular causes of tumors and creating medications that target those causes. RBX2 (RING box protein 2), also known as ROC2 (Regulator of Cullins 2), RNF7 (RING Finger Protein 7), or SAG (Sensitive to Apoptosis Gene) is a key component of the Cullin-RING-type E3 ubiquitin ligases (CRLs) and overexpressed in various human cancers. RBX2 is a potential drug target, the expression of which correlates with tumor staging, grading, and prognosis analysis. Through a synergistically biological interaction with Kras mutation in preclinical models, RBX2 accelerated the progression of skin cancer, pancreatic cancer, and lung cancer. In accordance, the aberrant expression of RBX2 will lead to dysregulation of many signaling pathways, which is crucial for tumor initiation and growth. However, the impact of RBX2 on tumors also intriguingly demonstrates a spatial reliance manner. In this review, we summarized the current understanding of RBX2 in multiple cancer types and suggested a significant potential of RBX2 as a therapeutic target.
癌症是人类健康面临的一个重大挑战。解决这个问题的关键方法之一是了解肿瘤的分子成因，并开发针对这些成因的药物。RBX2（RING 盒蛋白 2），也称为 ROC2（Cullin 调节因子 2）、RNF7（环指蛋白 7）或 SAG（凋亡敏感基因），是 Cullin-RING 型 E3 泛素连接酶（CRLs）的关键组成部分，在各种人类癌症中过度表达。RBX2 是一个潜在的药物靶点，其表达与肿瘤分期、分级和预后分析相关。通过与临床前模型中的 Kras 突变协同的生物学相互作用，RBX2 加速了皮肤癌、胰腺癌和肺癌的进展。相应地，RBX2 的异常表达会导致许多信号通路的失调，这对于肿瘤的发生和生长至关重要。然而，RBX2 对肿瘤的影响也具有引人注目的空间依赖性方式。在这篇综述中，我们总结了 RBX2 在多种癌症类型中的现有认识，并提出了 RBX2 作为治疗靶点的巨大潜力。
