依赖输血的地中海贫血患儿的血清微量营养素和抗氧化剂水平

Serum Micronutrients and Antioxidant Levels in Children With Transfusion-Dependent Thalassemia.

作者信息

Ray Sanghamitra, Vashisht Yachika, Saikia Diganta, Sharma Shikha, Kumar Manish

机构信息

Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi. Correspondence to: Dr Sanghamitra Ray, Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi - 110 031.

Department of Pediatrics, Chacha Nehru Bal Chikitsalaya, Geeta Colony, Delhi.

出版信息

Indian Pediatr. 2023 Dec 15;60(12):1005-1007. Epub 2023 Oct 10.

PMID:37822202

Abstract

OBJECTIVES

To estimate serum zinc, copper, magnesium and antioxidant levels in children with transfusion-dependent thalassemia (TDT).

METHODS

Cross-sectional study, enrolling children with TDT aged 3-14 years and age-matched healthy children without thalassemia. Serum zinc, copper, magnesium and total antioxidant capacity were estimated by direct colorimetric method and ELISA, respectively.

RESULTS

72 children (24 females; mean (SD) age 8.5 (3.2) years) were enrolled. Mean (SD) values of micronutrients in the study group and control group children were: serum zinc [89.4 (26.9) vs 93.5 (41.6) mg/dL; P=0.496], copper [118.3 (36.6) vs 123.3 (29.8) mg/L; P=0.133], magnesium [1.9 (0.3) vs 2.0 (0.2) mg/dL; P=0.015]. Total oxidant capacity level was not different in both the groups [median (range) 124.8 (16.0-501.7) vs 146.8 (14.0-641.7) mg/mL; P=0.605]. 24 (33%) children with TDT had low serum zinc levels (<65 mg/dL), and 31 (43%) had high serum copper levels (≥121 mg/L).

CONCLUSIONS

Children with TDT were found to have significantly lower magnesium levels compared to healthy children.

摘要

目的

评估依赖输血的地中海贫血（TDT）患儿的血清锌、铜、镁及抗氧化剂水平。

方法

横断面研究，纳入3至14岁的TDT患儿以及年龄匹配的无地中海贫血健康儿童。分别采用直接比色法和酶联免疫吸附测定法评估血清锌、铜、镁及总抗氧化能力。

结果

共纳入72名儿童（24名女性；平均（标准差）年龄8.5（3.2）岁）。研究组和对照组儿童的微量营养素平均（标准差）值分别为：血清锌[89.4（26.9）与93.5（41.6）mg/dL；P = 0.496]，铜[118.3（36.6）与123.3（29.8）mg/L；P = 0.133]，镁[1.9（0.3）与2.0（0.2）mg/dL；P = 0.015]。两组的总氧化剂能力水平无差异[中位数（范围）124.8（16.0 - 501.7）与146.8（14.0 - 641.7）mg/mL；P = 0.605]。24名（33%）TDT患儿血清锌水平低（<65 mg/dL），31名（43%）患儿血清铜水平高（≥121 mg/L）。