尼日利亚哮喘儿童血清锌、硒和总抗氧化剂含量：与疾病严重程度和症状控制的关系。

Serum Zinc, Selenium and Total Antioxidant Contents of Nigerian Children with Asthma: Association with Disease Severity and Symptoms Control.

机构信息

Department of Paediatrics and Child Health, Obafemi Awolowo University, Ile-Ife, 220282 Nigeria.

Department of Paediatrics, Wesley Guild Hospital Unit, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, 220282 Nigeria.

出版信息

J Trop Pediatr. 2020 Aug 1;66(4):395-402. doi: 10.1093/tropej/fmz078.

DOI:10.1093/tropej/fmz078

PMID:31747014

Abstract

BACKGROUND

Micronutrients and antioxidants may ameliorate oxidative stress. This study aimed to determine the serum Zinc (Zn), Selenium (Se) and Total Antioxidant Contents (TAC) of Nigerian children with asthma and relate these to disease severity and symptoms control.

METHODS

Children aged 2-15 years with asthma and age and sex matched controls were consecutively recruited. The children's serum Zn, Se and TAC were assayed and compared.

RESULTS

Eighty children each with asthma and controls participated in the study. Serum Zn (71.0 ± 30.3 µg/dl vs. 84.2 ± 31.7 µg/dl; p = 0.008), Se (67.3 ± 29.8 µg/l vs. 80.0 ± 31.7 µg/l; p = 0.033) and TAC [median (interquartile range) 5.2 (3.8-6.8) ng/dl vs. 6.2 (4.3-8.0) ng/dl; p = 0.019] were lower in children with asthma. Serum Se (65.7 ± 29.1 µg/l vs. 92.4 ± 28.6 µg/l; p = 0.001) was lower in those with moderate/severe than mild disease, but no association with symptoms control (p > 0.05).

CONCLUSION

Micronutrient supplementation may be beneficial in Nigerian children with asthma as they have relatively lower antioxidant micronutrients than nonasthmatics.

摘要

背景

微量营养素和抗氧化剂可能改善氧化应激。本研究旨在确定尼日利亚哮喘儿童的血清锌（Zn）、硒（Se）和总抗氧化剂含量（TAC），并将其与疾病严重程度和症状控制相关联。

方法

连续招募了年龄在 2-15 岁的患有哮喘和年龄、性别相匹配的对照儿童。检测并比较了儿童的血清 Zn、Se 和 TAC。

结果

共有 80 名哮喘儿童和对照儿童参加了研究。哮喘儿童的血清 Zn（71.0±30.3μg/dl 与 84.2±31.7μg/dl；p=0.008）、Se（67.3±29.8μg/l 与 80.0±31.7μg/l；p=0.033）和 TAC[中位数（四分位距）5.2（3.8-6.8）ng/dl 与 6.2（4.3-8.0）ng/dl；p=0.019]均低于对照组。中度/重度疾病儿童的血清 Se（65.7±29.1μg/l 与 92.4±28.6μg/l；p=0.001）低于轻度疾病儿童，但与症状控制无关（p>0.05）。