Samaha Carl, Chaaban Hadi, Simsek Cem, Danis Nilay, Lin Jessica S, Gurakar Ahmet
Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hepatol Forum. 2023 Sep 20;4(3):145-149. doi: 10.14744/hf.2023.2023.0030. eCollection 2023.
Living Donor Liver Transplantation (LDLT) is a valuable solution to the shortage of donor organs for patients with end-stage liver disease. However, the eligibility of obese donors for LDLT remains a subject of debate. This literature review explores global practices and perceptions of LDLT, identifies donor eligibility criteria, and discusses special considerations and ethical caveats. The review highlights the need for standardized guidelines for donor selection, considering the global distribution of Body mass index and variations in population-specific criteria. It also emphasizes the importance of non-invasive testing and pre-operative optimization of liver steatosis for select obese donors. Furthermore, the review examines the outcomes and complications associated with obese donors in LDLT. The findings of this review contribute to the ongoing discussion on the inclusion of obese donors in LDLT and provide insights for future research and guideline development.
活体肝移植（LDLT）是解决终末期肝病患者供体器官短缺问题的一种有效方法。然而，肥胖供体进行LDLT的资格仍然是一个有争议的话题。这篇文献综述探讨了全球范围内活体肝移植的实践和认知，确定了供体资格标准，并讨论了特殊考虑因素和伦理注意事项。该综述强调了制定标准化供体选择指南的必要性，要考虑到全球体重指数的分布情况以及特定人群标准的差异。它还强调了对选定的肥胖供体进行非侵入性检测和术前肝脏脂肪变性优化的重要性。此外，该综述研究了活体肝移植中肥胖供体的结局和并发症。这篇综述的结果有助于正在进行的关于肥胖供体纳入活体肝移植的讨论，并为未来的研究和指南制定提供见解。
