D'Souza Myfanwy J, Hundi Ganesh K, Dandekeri Sukumar, Jayaraman Jyothi
From the Department of Dermatology Venereology and Leprosy, Father Muller Medical College, Mangalore, Karnataka, India.
Indian J Dermatol. 2023 Jul-Aug;68(4):486. doi: 10.4103/ijd.ijd_366_22.
Many therapeutic modalities have been reported for the treatment of warts: a common bothersome condition; however, no single treatment is completely effective.
This study aimed to evaluate the efficacy and safety of intralesional injection of measles, mumps and rubella (MMR) vaccine and to compare its efficacy with 85% formic acid puncture for common warts.
This was a prospective comparative study.
A total of 60 patients, divided into two groups, were included in the study. Group A received an intralesional MMR vaccine of 0.3 ml per lesion, and group B received 85% formic acid puncture into each lesion with a maximum of 10 warts treated in each case. Five sessions were conducted every 2 weeks in each case with a follow-up period of 3 months to check for recurrence.
The Chi-square test, Fisher's test and -test were used for statistical analysis. A P-value <0.05 was considered statistically significant.
In group A, the complete response was observed in 62.5%, partial response in 8% and no response in 4.1% of patients. In group B, the complete response was observed in 31.8%, partial response in 63.6% and no response in 4.5% of patients. The difference in cure rates was found to be statistically significant with a value of 0.031. No recurrence was observed in both groups in the follow-up period.
Immunotherapy by intralesional MMR vaccine is a simple, well-tolerated, effective and cost-benefit modality for the treatment of warts and showed a statistically significant cure rate than formic acid therapy.
已报道多种治疗疣的方法，疣是一种常见的令人困扰的疾病，但尚无单一治疗方法能完全有效。
本研究旨在评估病灶内注射麻疹、腮腺炎和风疹（MMR）疫苗的疗效和安全性，并将其疗效与85%甲酸穿刺治疗寻常疣的疗效进行比较。
这是一项前瞻性对照研究。
共60例患者被纳入研究，分为两组。A组每个病灶注射0.3 ml的MMR疫苗，B组每个病灶进行85%甲酸穿刺，每个病例最多治疗10个疣。每组每2周进行5次治疗，随访3个月以检查复发情况。
采用卡方检验、Fisher检验和t检验进行统计分析。P值<0.05被认为具有统计学意义。
A组患者中，62.5%完全缓解，8%部分缓解，4.1%无缓解。B组患者中，31.8%完全缓解，63.6%部分缓解，4.5%无缓解。治愈率差异具有统计学意义，P值为0.031。随访期间两组均未观察到复发。
病灶内注射MMR疫苗进行免疫治疗是一种治疗疣的简单、耐受性好、有效且具有成本效益的方法，其治愈率比甲酸治疗具有统计学显著差异。
