Kharel Pramisha, Jia Chen, Dhital Kamal Raj, Chapagain Pukar, Aryal Sabita
From the Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Department of Dermatology, Radiant Health Care, Kathmandu, Nepal.
Indian J Dermatol. 2023 Jul-Aug;68(4):425-429. doi: 10.4103/ijd.ijd_885_22.
Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily (TNFSF). It acts through its receptor fibroblast growth factor-inducible 14 (Fn14). Studies have indicated that TWEAK/Fn14 pathway activation controls multiple cellular responses, including proliferation, angiogenesis and induction of inflammatory cytokines. TWEAK/Fn14 is manifested in many tissues of our body and most importantly in the skin causing inflammation and many autoimmune and neoplastic cutaneous disorders. Evidence suggests that the TWEAK/Fn14 axis, the downstream signalling pathway and its inflammatory molecular expressions are involved in the pathogenesis of many cutaneous disorders such as psoriasis, atopic dermatitis (AD) vitiligo and melanoma. So, this literature review describes a brief introduction of TWEAK and TWEAK/Fn14 pathway and summarises the case-series and open-label studies performed in the field of dermatology and its potential therapeutic benefit.
肿瘤坏死因子（TNF）样凋亡微弱诱导剂（TWEAK）是肿瘤坏死因子超家族（TNFSF）的成员。它通过其受体成纤维细胞生长因子诱导14（Fn14）发挥作用。研究表明，TWEAK/Fn14通路激活可控制多种细胞反应，包括增殖、血管生成和炎症细胞因子的诱导。TWEAK/Fn14在我们身体的许多组织中都有表现，最重要的是在皮肤中，会导致炎症以及许多自身免疫性和肿瘤性皮肤疾病。有证据表明，TWEAK/Fn14轴、下游信号通路及其炎症分子表达参与了许多皮肤疾病的发病机制，如银屑病、特应性皮炎（AD）、白癜风和黑色素瘤。因此，这篇文献综述简要介绍了TWEAK和TWEAK/Fn14通路，并总结了在皮肤病学领域进行的病例系列研究和开放标签研究及其潜在的治疗益处。
