血清肿瘤坏死因子样弱凋亡诱导因子：节段型与非节段型白癜风的分界点。

Serum TWEAK: A cutoff between segmental and nonsegmental vitiligo.

作者信息

El-Taweel Abd El-Aziz Ibrahim, Abdelrahman Amira Mohamed Noureldin, Sabry Sarah, Salem Rehab Mohammed

机构信息

Dermatology Department, Faculty of Medicine, Benha University, Benha, Egypt.

Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt.

出版信息

J Cosmet Dermatol. 2021 Mar;20(3):1017-1021. doi: 10.1111/jocd.13644. Epub 2020 Aug 17.

DOI:10.1111/jocd.13644

PMID:32808442

Abstract

BACKGROUND

TWEAK/Fn14 is expressed in many tissues including the skin, playing an important role in many inflammatory, autoimmune, and neoplastic cutaneous disorders.

AIMS

To assess the serum levels of tumor necrosis factor-like weak inducer of apoptosis (TWEAK) in vitiligo patients.

METHODS

This case-control study included 100 subjects (50 vitiligo patients and 50 control subjects) recruited from Dermatology Outpatient Clinic, Benha University. All patients were subjected to complete cutaneous examination, to evaluate the clinical type, distribution and severity of vitiligo using the Vitiligo Area Scoring Index (VASI).

RESULTS

TWEAK serum levels were significantly higher in patients than in the control subjects (644.76 ± 688.93 vs 282.75 ± 125.67, respectively). Serum levels were significantly elevated in segmental versus nonsegmental vitiligo. Receiver operating characteristic (ROC) analysis revealed that TWEAK shows 80% sensitivity and 56.67% specificity in diagnosing vitiligo and 100% sensitivity and 80.09% specificity in differentiating segmental from nonsegmental vitiligo.

CONCLUSION

TWEAK may play a role in vitiligo pathogenesis. It may be used in the differentiation between segmental and nonsegmental vitiligo and represent a promising therapeutic target in vitiligo.

摘要

背景

肿瘤坏死因子样凋亡弱诱导因子（TWEAK）/成纤维细胞生长因子诱导 14（Fn14）在包括皮肤在内的许多组织中表达，在多种炎症性、自身免疫性和肿瘤性皮肤疾病中发挥重要作用。

目的

评估白癜风患者血清中肿瘤坏死因子样凋亡弱诱导因子（TWEAK）的水平。

方法

本病例对照研究纳入了从贝纳大学皮肤科门诊招募的 100 名受试者（50 例白癜风患者和 50 例对照受试者）。所有患者均接受全面的皮肤检查，使用白癜风面积评分指数（VASI）评估白癜风的临床类型、分布和严重程度。

结果

患者的 TWEAK 血清水平显著高于对照受试者（分别为 644.76 ± 688.93 和 282.75 ± 125.67）。节段型白癜风患者的血清水平显著高于非节段型。受试者工作特征（ROC）分析显示，TWEAK 在诊断白癜风时的敏感性为 80%，特异性为 56.67%；在区分节段型和非节段型白癜风时的敏感性为 100%，特异性为 80.09%。