Key Laboratory of Food Nutrition and Functional Food of Hainan Province, School of Food Science and Engineering, Hainan University, Haikou 570228, China.
ClassyKiss Dairy (Shenzhen) Co., Ltd, China.
Food Funct. 2023 Oct 30;14(21):9580-9590. doi: 10.1039/d3fo02618c.
To investigate the effect of probiotic CKCC1858, LF on the prevention of hyperlipidemia and its correlation with gut microbiota, golden hamsters were fed a high-fat diet alone or in combination with the probiotic for 6 weeks. The results showed that the LF intervention alleviated HFD-induced hyperlipidemia and liver damage, as evidenced by the reduced serum lipid profile levels and liver function markers. More importantly, the LF intervention attenuated HFD-induced microbiota dysbiosis by enhancing the abundance of SCFA-producing bacteria and reshaping the metabolic functions of the gut microbiota, likely contributing to its pronounced preventive effects on hyperlipidemia. This study elucidated the mechanism of the preventive effect of probiotics on hyperlipidemia in terms of regulating gut microbiota, and provided suggestions for regulating gut microbiota through probiotic interventions to improve lipid metabolism.
为了研究益生菌 CKCC1858、LF 对高脂血症的预防作用及其与肠道微生物群的相关性，我们用高脂饲料单独或联合益生菌喂养金黄地鼠 6 周。结果表明，LF 干预减轻了 HFD 诱导的高脂血症和肝损伤，表现为血清脂质谱水平和肝功能标志物降低。更重要的是，LF 干预通过增强产 SCFA 细菌的丰度和重塑肠道微生物群的代谢功能，减轻了 HFD 诱导的微生物群失调，这可能是其对高脂血症的显著预防作用的原因。本研究从调节肠道微生物群的角度阐明了益生菌预防高脂血症的作用机制，并为通过益生菌干预调节肠道微生物群以改善脂质代谢提供了建议。
