Center of Excellence in Stroke, Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Department of Emergency Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
Ir J Med Sci. 2024 Apr;193(2):967-972. doi: 10.1007/s11845-023-03541-0. Epub 2023 Oct 12.
The novel coronavirus, SARS-CoV-2, can lead to potential neurological complications in COVID-19 patients. This study aims to assess the prevalence and associated risk factors of these complications among Thai individuals.
We conducted a retrospective study on hospitalized adults with COVID-19 at Thammasat University Hospital from April 2020 to September 2021, totaling 990 patients. We used propensity score matching and logistic regression to determine associated risk factors.
Of the patients, 21.7% (215 individuals) manifested neurological complications, categorized as follows: Skeletal muscle injury: 16.3% Acute cerebrovascular disease: 0.8% Delirium: 2.4% Impaired consciousness: 2.6% Seizures: 0.5% Post-matching revealed risk factors significantly associated with neurological complications: overweight status, hypertension, diabetes mellitus, dyslipidemia, and severe infection. However, in a multivariable analysis, only severe infection remained significant (adjusted OR 3.71; p = 0.010). The presence of neurological complications was linked with an elevated mortality risk (OR 1.77, p = 0.005).
In the Thai COVID-19 patient cohort, roughly 22% experienced neurological complications, with severe infection standing out as a major risk factor. This underscores the importance of closely monitoring neurological symptoms in COVID-19 patients.
新型冠状病毒（SARS-CoV-2）可导致 COVID-19 患者出现潜在的神经并发症。本研究旨在评估泰国人群中这些并发症的患病率及相关危险因素。
我们对 2020 年 4 月至 2021 年 9 月在泰国玛希隆大学医院住院的 COVID-19 成年患者进行了回顾性研究，共纳入 990 例患者。我们采用倾向评分匹配和 logistic 回归分析确定相关危险因素。
患者中有 21.7%（215 例）出现了神经并发症，分类如下：骨骼肌损伤：16.3%；急性脑血管病：0.8%；谵妄：2.4%；意识障碍：2.6%；癫痫发作：0.5%。匹配后，有显著意义的神经并发症相关危险因素为超重、高血压、糖尿病、血脂异常和严重感染。但多变量分析显示，只有严重感染有统计学意义（校正 OR 3.71，p=0.010）。有神经并发症与死亡率升高相关（OR 1.77，p=0.005）。
在泰国 COVID-19 患者人群中，约有 22%出现了神经并发症，严重感染是主要危险因素。这提示我们应密切监测 COVID-19 患者的神经症状。
