Lovell C R, Nicholls A C, Duance V C, Bailey A J
Br J Dermatol. 1979 Apr;100(4):359-69. doi: 10.1111/j.1365-2133.1979.tb01635.x.
The amount of dermal collagen is increased in systemic sclerosis. However, unlike certain inflammatory conditions, the relative proportions of Type I and Type III collagens are closely similar to those found in normal adult dermis. Similarly, no change in the distribution of the collagen types could be detected by immunofluorescent staining, although a considerable thickening of the epidermis was clearly evident in all the sclerotic lesions examined.
系统性硬化症中真皮胶原蛋白的含量会增加。然而，与某些炎症性疾病不同，I型和III型胶原蛋白的相对比例与正常成人真皮中的比例非常相似。同样，尽管在所有检查的硬化性病变中表皮明显增厚，但通过免疫荧光染色未检测到胶原蛋白类型分布的变化。
