Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology, Central South University, Changsha 410008, China.
ACS Appl Bio Mater. 2023 Nov 20;6(11):4694-4702. doi: 10.1021/acsabm.3c00492. Epub 2023 Oct 12.
A copper selenide-embedded gellan gum hydrogel (CuSe@GG) is designed as an "all-in-one" antitumor agent. The obtained nanocomposite hydrogel exhibits strong near-infrared light absorption and high photothermal conversion efficiency in both the NIR-I and NIR-II biowindows. The photothermal conversion efficiency achieves 58.8% under the irradiation of 0.75 W/cm with a 1064 nm laser. Furthermore, the nanocomposite hydrogel has catalase- and peroxidase-mimicking activities, which could alter the tumor microenvironment by reducing hypoxia and/or increasing the production of reactive oxygen species. Moreover, the multifunctional CuSe@GG nanocomposite hydrogel can also be used as an immune agonist resiquimod (R848) carrier to promote immune regulation and enhance the therapeutic effect. The single-syringe R848/CuSe@GG treatment achieves synergetic photothermal immunotherapy, showing 97.4% of tumor regression rate from an initial large tumor of 300 mm.
一种嵌入硒化铜的结冷胶水凝胶（CuSe@GG）被设计为一种“一体化”的抗肿瘤剂。所得到的纳米复合水凝胶在近红外-I 和近红外-II 生物窗口中都表现出很强的近红外光吸收和高光热转换效率。在 1064nm 激光照射下，0.75W/cm 的光功率下，光热转换效率达到 58.8%。此外，纳米复合水凝胶具有过氧化氢酶和过氧化物酶模拟活性，可通过减少缺氧和/或增加活性氧的产生来改变肿瘤微环境。此外，多功能的 CuSe@GG 纳米复合水凝胶还可以用作免疫激动剂瑞喹莫德（R848）的载体，以促进免疫调节并增强治疗效果。单注射器 R848/CuSe@GG 治疗实现了协同光热免疫治疗，使初始 300mm 大肿瘤的肿瘤退缩率达到 97.4%。
