Innovation Center of the Faculty of Technology and Metallurgy in Belgrade Ltd, Belgrade, Serbia.
School of Materials Science and Engineering, Shanghai Jiao Tong University, Shanghai, People's Republic of China.
Biomed Mater. 2023 Oct 26;18(6). doi: 10.1088/1748-605X/ad02d2.
The restoration of large bone defects caused by trauma, tumor resection, or infection is a major clinical problem in orthopedics and dentistry because postoperative infections, corrosion, and limited osteointegration of metal implants can lead to loosening of the implant. The aim of this study was to improve the surface properties of a 3D-printed (electron beam melting) Ti6Al4V-based macroporous scaffold by multilayer coating with bioactive silicate glasses (BAGs) and hydroxyapatite doped with a silver (AgHAP) or AgHAP additionally sonochemically modified with ZnO (ZnO-AgHAP). The coated scaffolds AgHAP_BAGs_Ti and ZnO-AgHAP_BAGs_Ti enhanced cytocompatibility in L929 and MRC5 cell lines and expressed bioactivity in simulated body fluid. A lower release of vanadium ions in coated samples compared to bare Ti scaffold indicates decreased dissolution of Ti alloy in coated samples. The coated samples reduced growth ofandfor 4-6 orders of magnitude. Therefore, the 3D-printed Ti-based scaffolds coated with BAGs and (ZnO-)AgHAP have great potential for application as a multifunctional implant with antibacterial properties for the restoration of defects in load-bearing bones.
创伤、肿瘤切除或感染导致的大骨缺损的修复是骨科和牙科的一个主要临床问题，因为术后感染、腐蚀和金属植入物有限的骨整合会导致植入物松动。本研究旨在通过用生物活性硅酸盐玻璃（BAG）和掺银的羟基磷灰石（AgHAP）或另外用氧化锌（ZnO-AgHAP）进行超声化学改性的羟基磷灰石（AgHAP）多层涂层来改善 3D 打印（电子束熔化）Ti6Al4V 基大孔支架的表面性能。涂层支架 AgHAP_BAGs_Ti 和 ZnO-AgHAP_BAGs_Ti 增强了 L929 和 MRC5 细胞系中的细胞相容性，并在模拟体液中表达了生物活性。与裸 Ti 支架相比，涂层样品中钒离子的释放量较低，表明 Ti 合金在涂层样品中的溶解减少。涂层样品使和的生长降低了 4-6 个数量级。因此，涂有 BAGs 和（ZnO-）AgHAP 的 3D 打印 Ti 基支架具有作为具有抗菌性能的多功能植入物用于修复承重骨缺损的巨大潜力。
