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用于体外研究中增强骨整合的Ti6Al4V支架的3D打印与表面工程

3D Printing and Surface Engineering of Ti6Al4V Scaffolds for Enhanced Osseointegration in an In Vitro Study.

作者信息

Ma Changyu, de Barros Natan Roberto, Zheng Tianqi, Gomez Alejandro, Doyle Marshall, Zhu Jianhao, Nanda Himansu Sekhar, Li Xiaochun, Khademhosseini Ali, Li Bingbing

机构信息

Autonomy Research Center for STEAHM, California State University Northridge, Northridge, CA 91324, USA.

Terasaki Institute for Biomedical Innovation, Los Angeles, CA 90024, USA.

出版信息

Biomimetics (Basel). 2024 Jul 10;9(7):423. doi: 10.3390/biomimetics9070423.

DOI:10.3390/biomimetics9070423
PMID:39056864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11274417/
Abstract

Ti6Al4V superalloy is recognized as a good candidate for bone implants owing to its biocompatibility, corrosion resistance, and high strength-to-weight ratio. While dense metal implants are associated with stress shielding issues due to the difference in densities, stiffness, and modulus of elasticity compared to bone tissues, the surface of the implant/scaffold should mimic the properties of the bone of interest to assure a good integration with a strong interface. In this study, we investigated the additive manufacturing of porous Ti6Al4V scaffolds and coating modification for enhanced osteoconduction using osteoblast cells. The results showed the successful fabrication of porous Ti6Al4V scaffolds with adequate strength. Additionally, the surface treatment with NaOH and Dopamine Hydrochloride (DOPA) promoted the formation of Dopamine Hydrochloride (DOPA) coating with an optimized coating process, providing an environment that supports higher cell viability and growth compared to the uncoated Ti6Al4V scaffolds, as demonstrated by the higher proliferation ratios observed from day 1 to day 29. These findings bring valuable insights into the surface modification of 3D-printed scaffolds for improved osteoconduction through the coating process in solutions.

摘要

Ti6Al4V 超级合金因其生物相容性、耐腐蚀性和高比强度而被认为是骨植入物的理想候选材料。虽然致密金属植入物由于其与骨组织在密度、刚度和弹性模量方面存在差异而与应力屏蔽问题相关，但植入物/支架的表面应模仿目标骨的特性，以确保通过强界面实现良好的整合。在本研究中，我们研究了多孔Ti6Al4V支架的增材制造以及使用成骨细胞进行涂层改性以增强骨传导性。结果表明成功制造出了具有足够强度的多孔Ti6Al4V支架。此外，通过优化的涂层工艺，用氢氧化钠和盐酸多巴胺（DOPA）进行表面处理促进了盐酸多巴胺（DOPA）涂层的形成，与未涂层的Ti6Al4V支架相比，提供了一个支持更高细胞活力和生长的环境，从第1天到第29天观察到的更高增殖率证明了这一点。这些发现为通过溶液中的涂层工艺对3D打印支架进行表面改性以改善骨传导性带来了有价值的见解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/b2422b2e3517/biomimetics-09-00423-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/981c7072a624/biomimetics-09-00423-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/795d3c481e03/biomimetics-09-00423-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/71eeacbf3358/biomimetics-09-00423-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/70bbffcc21f9/biomimetics-09-00423-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/97bc2a06a14b/biomimetics-09-00423-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/6588e4c4442e/biomimetics-09-00423-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/b2422b2e3517/biomimetics-09-00423-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/981c7072a624/biomimetics-09-00423-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/795d3c481e03/biomimetics-09-00423-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/71eeacbf3358/biomimetics-09-00423-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/70bbffcc21f9/biomimetics-09-00423-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/97bc2a06a14b/biomimetics-09-00423-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/6588e4c4442e/biomimetics-09-00423-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bd9d/11274417/b2422b2e3517/biomimetics-09-00423-g007.jpg

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