Department of Neonatology, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, 15704, Spain; IDIS-Health Research Institute of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain.
IDIS-Health Research Institute of Santiago de Compostela, Santiago de Compostela, 15704, Spain; Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, Madrid, Spain.
Environ Pollut. 2023 Dec 15;339:122705. doi: 10.1016/j.envpol.2023.122705. Epub 2023 Oct 10.
Recent years have seen growing interest in hair sample analysis to detect organic pollutants (OPs). This biological matrix can be analysed non-invasively for biomonitoring of OPs over a wide exposure window. Obtaining hair sample amounts that meet the needs of the analytical methodology required for the determination of the POs of interest can be challenging, especially in infants. As a result, studies assessing organic pollutants in infant hair have been very scarce. We quantified levels of about 60 OPs, including persistent organic pollutants (POPs), in 110 hair samples from a patient cohort (60 mothers and 50 infants) from Santiago de Compostela (north-western Spain). For each participant we examined relationship between OP levels and corresponding epidemiological parameters using correlations, principal component analysis (PCA), hierarchical cluster analysis, and Multivariate analysis of variance (MANOVA). For many OPs we observed significant correlations with place of residence, parity, and maternal age, as well as pet ownership. Evaluation of dietary habits showed significant associations between levels some OPs and the consumption of fish, molluscs, and cereal. There were significant associations between chlorpyrifos and deltamethrin levels and infant birth characteristics such as birthweight and head circumference. Relations between OP levels in the hair of mothers and their infants were also examined, revealing common sources of exposure for dioxin-like polychlorinated biphenyls (DLPCBs), non-dioxin-like polychlorinated biphenyls (NDLPCBs), polybrominated diphenyl ethers (PBDEs), and polycyclic aromatic hydrocarbons (PAHs). Levels of fluoranthene (F), pyrene (P), endrin, and some PBDEs in maternal hair were significantly correlated with those in infant hair. Our findings identified common sources of exposure to OPs of distinct chemical classes.
近年来，人们对通过分析头发样本来检测有机污染物（OPs）的方法产生了浓厚的兴趣。这种生物基质可以进行非侵入性分析，以便在广泛的暴露窗口内对 OPs 进行生物监测。获得满足分析方法学要求的头发样本量可能具有挑战性，特别是在婴儿中。因此，评估婴儿头发中有机污染物的研究非常有限。我们对来自西班牙西北部圣地亚哥-德孔波斯特拉的一个患者队列（60 名母亲和 50 名婴儿）的 110 个头发样本中约 60 种 OPs （包括持久性有机污染物（POPs））进行了定量分析。对于每个参与者，我们使用相关性、主成分分析（PCA）、层次聚类分析和多元方差分析（MANOVA）来研究 OP 水平与相应的流行病学参数之间的关系。对于许多 OPs，我们观察到与居住地、生育次数和母亲年龄以及宠物拥有情况之间存在显著相关性。对饮食习惯的评估表明，一些 OPs 的水平与鱼类、贝类和谷物的消耗之间存在显著关联。氯吡硫磷和溴氰菊酯的水平与婴儿出生特征（如出生体重和头围）之间存在显著关联。还检查了母亲和婴儿头发中 OP 水平之间的关系，揭示了二恶英类多氯联苯（DLPCBs）、非二恶英类多氯联苯（NDLPCBs）、多溴联苯醚（PBDEs）和多环芳烃（PAHs）的共同暴露源。母亲头发中的荧蒽（F）、芘（P）、艾氏剂和一些 PBDEs 水平与婴儿头发中的水平显著相关。我们的研究结果确定了不同化学类别的 OPs 的共同暴露源。
