School of Materials Science and Engineering, Jilin University, Changchun 130022, China.
Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164, China.
Int J Biol Macromol. 2023 Dec 31;253(Pt 6):127364. doi: 10.1016/j.ijbiomac.2023.127364. Epub 2023 Oct 10.
As an important organ of the human body, effective protection of the skin during trauma is crucial. An ideal wound dressing should have adhesion, adsorption of wound secretions, and good antibacterial properties. Two kinds of natural polysaccharide-based hydrogels, carboxyethyl chitosan/oxidized pectin hydrogel (CEC/OP) and carboxyethyl chitosan/oxidized pectin/polyethyleneimine hydrogel (CEC/OP/PEI), were reported by using carboxyethyl chitosan as the matrix, and oxidized pectin and branched polyethyleneimine as the crosslinking agents. Both hydrogels could be formed in a short time and exhibited the pH responsively due to the presence of imine bond. Compared with carboxyethyl chitosan/oxidized pectin hydrogel, polyethyleneimine containing hydrogel can form gel quickly, a more compact and stable three-dimensional space network structure was formed, which exhibited better swelling performance, the swelling ration, rheology property, self-repair ability, and antibacterial performance. When the mass fractions of carboxyethyl chitosan and oxidized pectin solutions are 4 wt% and 9 wt%, respectively, the hydrogel exhibited an antibacterial efficiency of >96 % against both Staphylococcus aureus and Escherichia coli. After adding 0.75 wt% polyethyleneimine, the antibacterial efficiency of hydrogel could reach up to >98 %. More importantly, the polyethyleneimine containing hydrogel has a significant effect in the treatment of bacterially infected wounds.
作为人体的重要器官，在创伤时有效地保护皮肤至关重要。理想的伤口敷料应具有粘性、吸附伤口分泌物和良好的抗菌性能。两种基于天然多糖的水凝胶，羧乙基壳聚糖/氧化果胶水凝胶（CEC/OP）和羧乙基壳聚糖/氧化果胶/聚乙烯亚胺水凝胶（CEC/OP/PEI），通过使用羧乙基壳聚糖作为基质，氧化果胶和支化聚乙烯亚胺作为交联剂来报道。两种水凝胶都可以在短时间内形成，并由于亚胺键的存在表现出 pH 响应性。与羧乙基壳聚糖/氧化果胶水凝胶相比，含聚乙烯亚胺的水凝胶能够快速形成凝胶，形成更紧凑和稳定的三维空间网络结构，表现出更好的溶胀性能、流变性能、自修复能力和抗菌性能。当羧乙基壳聚糖和氧化果胶溶液的质量分数分别为 4wt%和 9wt%时，水凝胶对金黄色葡萄球菌和大肠杆菌的抑菌效率均>96%。加入 0.75wt%的聚乙烯亚胺后，水凝胶的抑菌效率可达>98%。更重要的是，含聚乙烯亚胺的水凝胶在治疗细菌感染伤口方面有显著效果。
