College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
College of Chemistry & Pharmacy, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
Colloids Surf B Biointerfaces. 2022 Oct;218:112738. doi: 10.1016/j.colsurfb.2022.112738. Epub 2022 Jul 28.
Hydrogels have been used widely as wound dressings for maintaining a moist environment to rapid wound healing. However, the lack of antibacterial effect limits their further applications. Herein, we developed a polysaccharide-based hydrogel that can achieve photothermal-assisted bacterial inactivation. The hydrogel has inherent antibacterial activity due to introduction of quaternised chitosan (QCS) with a protonated amine group-modified hydrophilic polycationic structure. Under near infrared (NIR) irradiation, the antibacterial effect of the hydrogel was significantly improved because thermal ablation could also combat bacteria. The hydrogel showed self-healing property through reversible Schiff base bonds between QCS and oxidized hyaluronic acid (OHA). The hydrogel is also pH-sensitive to release drugs in acidic wound. The full-thickness skin defect model showed it had a promoting effect on wound healing. Overall, we provide a theoretical basis for a promising wound dressing based on a photothermally improved polysaccharide-based hydrogel with self-healing/pH-responsive/inherently antibacterial capacity.
水凝胶已被广泛用作伤口敷料，以保持湿润的环境，促进伤口快速愈合。然而，缺乏抗菌效果限制了它们的进一步应用。在此，我们开发了一种基于多糖的水凝胶，可实现光热辅助细菌失活。由于引入了具有质子化胺基修饰的亲水性聚阳离子结构的季铵化壳聚糖（QCS），水凝胶具有内在的抗菌活性。在近红外（NIR）照射下，由于热消融也可以对抗细菌，水凝胶的抗菌效果得到了显著提高。水凝胶通过 QCS 和氧化透明质酸（OHA）之间的可逆席夫碱键具有自修复性能。水凝胶还对 pH 敏感，可以在酸性伤口中释放药物。全层皮肤缺损模型表明，它对伤口愈合有促进作用。总的来说，我们为一种基于光热改善的具有自修复/ pH 响应/固有抗菌能力的多糖基水凝胶的有前途的伤口敷料提供了理论依据。
