• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Rethinking placebos: embracing synthetic control arms in clinical trials for rare tumors.

作者信息

Serrano César, Rothschild Sara, Villacampa Guillermo, Heinrich Michael C, George Suzanne, Blay Jean-Yves, Sicklick Jason K, Schwartz Gary K, Rastogi Sameer, Jones Robin L, Rutkowski Piotr, Somaiah Neeta, Navarro Víctor, Evans Denisse, Trent Jonathan C

机构信息

Department of Medical Oncology, Vall d'Hebron University Hospital, Barcelona, Spain.

Sarcoma Translational Research Program, Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain.

出版信息

Nat Med. 2023 Nov;29(11):2689-2692. doi: 10.1038/s41591-023-02578-z.

DOI:10.1038/s41591-023-02578-z
PMID:37828359
Abstract
摘要

相似文献

1
Rethinking placebos: embracing synthetic control arms in clinical trials for rare tumors.重新思考安慰剂：在罕见肿瘤临床试验中采用合成对照臂。
Nat Med. 2023 Nov;29(11):2689-2692. doi: 10.1038/s41591-023-02578-z.
2
[Methodology of the evaluation of success in the therapy of tumors].[肿瘤治疗成功评估方法学]
Verh Dtsch Ges Inn Med. 1967;73:495-504.
3
Rethinking cancer clinical trials for the future.对未来癌症临床试验的重新思考。
Future Oncol. 2014;10(9):1545-7. doi: 10.2217/fon.14.95.
4
[Problems posed by therapeutic trials in an anticancer center: apropos of 3 current trials].[抗癌中心治疗试验所带来的问题：关于三项当前试验]
Bull Cancer. 1974 Apr-Jun;61(2):281-4.
5
[Predictive pathology: concept and dimensions of clinical trials].[预测病理学：临床试验的概念与维度]
Verh Dtsch Ges Pathol. 2006;90:52-8.
6
Levamisole or placebo after effective chemotherapy for remission and survival prolongation in advanced human solid tumors--a double-blind randomized trial.左旋咪唑或安慰剂用于晚期人类实体瘤有效化疗后的缓解及生存延长——一项双盲随机试验
Acta Oncol. 1989;28(1):105-6. doi: 10.3109/02841868909111190.
7
AIDS trials, civil liberties and the social control of therapy: should we embrace new drugs with open arms?艾滋病试验、公民自由与治疗的社会控制：我们应该欣然接受新药吗？
CMAJ. 1990 May 15;142(10):1057-62.
8
Letter: Levamisole.信件：左旋咪唑。
Lancet. 1975 Feb 15;1(7903):389.
9
Rethinking clinical trials for cytostatic drugs.重新思考细胞毒性药物的临床试验。
Nat Rev Cancer. 2003 Jul;3(7):540-5. doi: 10.1038/nrc1124.
10
Researching the cost of research.研究研究的成本。
J Clin Oncol. 2003 Nov 15;21(22):4081-2. doi: 10.1200/JCO.2003.08.972. Epub 2003 Oct 14.

引用本文的文献

1
Matching placebo development for injectable biologics-a practical tutorial.注射用生物制品的匹配安慰剂开发——实用指南
Antib Ther. 2025 May 8;8(3):177-188. doi: 10.1093/abt/tbaf009. eCollection 2025 Jul.
2
Larotrectinib Compared With Real-World Non-Tropomyosin Receptor Kinase Inhibitor Therapies in Patients With Tropomyosin Receptor Kinase Fusion Cancer.拉罗替尼与原肌球蛋白受体激酶融合癌患者的真实世界非原肌球蛋白受体激酶抑制剂疗法的比较
JCO Precis Oncol. 2025 Apr;9:e2400500. doi: 10.1200/PO-24-00500. Epub 2025 Apr 23.
3
Synthetic Data in Healthcare and Drug Development: Definitions, Regulatory Frameworks, Issues.

本文引用的文献

1
The next generation of evidence-based medicine.循证医学的下一代。
Nat Med. 2023 Jan;29(1):49-58. doi: 10.1038/s41591-022-02160-z. Epub 2023 Jan 16.
2
Audit of Data Sharing by Pharmaceutical Companies for Anticancer Medicines Approved by the US Food and Drug Administration.美国食品和药物管理局批准的抗癌药物的制药公司的数据共享审核。
JAMA Oncol. 2022 Sep 1;8(9):1310-1316. doi: 10.1001/jamaoncol.2022.2867.
3
Pimitespib in patients with advanced gastrointestinal stromal tumor (CHAPTER-GIST-301): a randomized, double-blind, placebo-controlled phase III trial.
医疗保健与药物研发中的合成数据：定义、监管框架、问题
CPT Pharmacometrics Syst Pharmacol. 2025 May;14(5):840-852. doi: 10.1002/psp4.70021. Epub 2025 Apr 7.
4
Patient-derived xenograft models of gastrointestinal stromal tumors provide a ready-to-use platform for translational research.胃肠道间质瘤的患者来源异种移植模型为转化研究提供了一个现成可用的平台。
Dis Model Mech. 2025 Feb 1;18(2). doi: 10.1242/dmm.052225. Epub 2025 Feb 21.
5
Novel clinical trial designs emerging from the molecular reclassification of cancer.源于癌症分子重新分类的新型临床试验设计。
CA Cancer J Clin. 2025 May-Jun;75(3):243-267. doi: 10.3322/caac.21880. Epub 2025 Jan 22.
6
AI meets real-world patients.人工智能与现实世界中的患者相遇。
Nat Biotechnol. 2024 Oct;42(10):1475. doi: 10.1038/s41587-024-02455-1.
7
A Head-to-Head Comparison of the First-Line Treatments for Locally Advanced or Metastatic Urothelial Cancer: Is There Still a Role for Chemotherapy?局部晚期或转移性尿路上皮癌一线治疗的头对头比较：化疗是否仍有作用？
Cancers (Basel). 2024 Jun 29;16(13):2400. doi: 10.3390/cancers16132400.
8
Efficacy and Safety of Ripretinib in Advanced Gastrointestinal Stromal Tumors within an Expanded Access Program: A Cohort Study.扩大准入项目中瑞派替尼治疗晚期胃肠道间质瘤的疗效与安全性：一项队列研究
Cancers (Basel). 2024 Feb 28;16(5):985. doi: 10.3390/cancers16050985.
9
Novel trial designs for patients with gastrointestinal stromal tumor.胃肠道间质瘤患者的新型试验设计
ESMO Open. 2024 Jan;9(1):102218. doi: 10.1016/j.esmoop.2023.102218. Epub 2024 Jan 8.
吡咯烷二硫代氨基甲酸酯（Pimitespib）治疗晚期胃肠道间质瘤（CHAPTER-GIST-301）患者的随机、双盲、安慰剂对照 III 期临床试验。
Ann Oncol. 2022 Sep;33(9):959-967. doi: 10.1016/j.annonc.2022.05.518. Epub 2022 Jun 8.
4
The GIST of Advances in Treatment of Advanced Gastrointestinal Stromal Tumor.胃肠道间质瘤治疗进展的要点。
Am Soc Clin Oncol Educ Book. 2022 Apr;42:1-15. doi: 10.1200/EDBK_351231.
5
External control arms in oncology: current use and future directions.肿瘤学中的外部对照臂：当前应用与未来方向。
Ann Oncol. 2022 Apr;33(4):376-383. doi: 10.1016/j.annonc.2021.12.015. Epub 2022 Jan 10.
6
IPDfromKM: reconstruct individual patient data from published Kaplan-Meier survival curves.KM-IPD: 从已发表的 Kaplan-Meier 生存曲线中重建个体患者数据。
BMC Med Res Methodol. 2021 Jun 1;21(1):111. doi: 10.1186/s12874-021-01308-8.
7
Ripretinib in patients with advanced gastrointestinal stromal tumours (INVICTUS): a double-blind, randomised, placebo-controlled, phase 3 trial.瑞派替尼治疗晚期胃肠道间质瘤患者（INVICTUS）：一项双盲、随机、安慰剂对照、III 期临床试验。
Lancet Oncol. 2020 Jul;21(7):923-934. doi: 10.1016/S1470-2045(20)30168-6. Epub 2020 Jun 5.
8
Burden and centralised treatment in Europe of rare tumours: results of RARECAREnet-a population-based study.欧洲罕见肿瘤的负担和集中治疗：RARECAREnet 一项基于人群的研究结果。
Lancet Oncol. 2017 Aug;18(8):1022-1039. doi: 10.1016/S1470-2045(17)30445-X. Epub 2017 Jul 4.
9
Evolution of Randomized Trials in Advanced/Metastatic Soft Tissue Sarcoma: End Point Selection, Surrogacy, and Quality of Reporting.晚期/转移性软组织肉瘤随机试验的演变：终点选择、替代指标及报告质量
J Clin Oncol. 2016 May 1;34(13):1469-75. doi: 10.1200/JCO.2015.64.3437. Epub 2016 Mar 7.
10
Rare Cancers Europe (RCE) methodological recommendations for clinical studies in rare cancers: a European consensus position paper.欧洲罕见癌症临床研究的方法学建议：一份欧洲共识立场文件
Ann Oncol. 2015 Feb;26(2):300-6. doi: 10.1093/annonc/mdu459. Epub 2014 Oct 1.