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氧摄取分数在人脑内并不均匀：一项正电子发射断层扫描研究。

Oxygen extraction fraction is not uniform in human brain: a positron emission tomography study.

机构信息

Department of Radiology and Nuclear Medicine, Fukushima Medical University, 1 Hikariga-Oka, Fukushima, 960-1295, Japan.

Advanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan.

出版信息

J Physiol Sci. 2023 Oct 12;73(1):25. doi: 10.1186/s12576-023-00880-6.

DOI:10.1186/s12576-023-00880-6
PMID:37828449
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10717292/
Abstract

The regional differences in cerebral oxygen extraction fraction (OEF) in brain were investigated using positron emission tomography (PET) in detail with consideration of systemic errors in PET measurement estimated by simulation studies. The cerebral blood flow (CBF), cerebral blood volume (CBV), OEF, and cerebral metabolic rate of oxygen (CMRO) were measured on healthy men by PET with O-labeled gases. The OEF values in the pons and the parahippocampal gyrus were significantly smaller than in the other brain regions. The OEF value in the lateral side of the occipital cortex was largest among the cerebral cortical regions. Simulation studies have revealed that errors in OEF caused by regional differences in the distribution volume of O-labeled water, as well as errors in OEF caused by a mixture of gray and white matter, must be negligible. The regional differences in OEF in brain must exist which might be related to physiological meanings.Article title: Kindly check and confirm the edit made in the article title.I have checked the article title and it is OK as is. Trial registration: The UMIN clinical trial number: UMIN000033382, https://www.umin.ac.jp/ctr/index.htm.

摘要

使用正电子发射断层扫描 (PET) 详细研究了脑氧摄取分数 (OEF) 的区域差异，并通过模拟研究估计了 PET 测量中的系统误差。通过使用 O 标记气体的 PET 测量，对健康男性的脑血流量 (CBF)、脑血容量 (CBV)、OEF 和脑氧代谢率 (CMRO) 进行了测量。脑桥和海马旁回的 OEF 值明显小于其他脑区。大脑皮质区域中，枕叶外侧皮质的 OEF 值最大。模拟研究表明，由 O 标记水分布容积的区域差异引起的 OEF 误差，以及由灰质和白质混合引起的 OEF 误差，必须可以忽略不计。脑的 OEF 区域差异必然存在，这可能与生理意义有关。文章标题：请检查并确认文章标题中的编辑。我已检查文章标题，无需修改。试验注册：UMIN 临床试验编号：UMIN000033382，https://www.umin.ac.jp/ctr/index.htm。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/bff8f40302c8/12576_2023_880_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/94cbffcdd263/12576_2023_880_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/fd737b1dddbd/12576_2023_880_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/0974acf91870/12576_2023_880_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/8f2051359180/12576_2023_880_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/fb590ca97874/12576_2023_880_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/bff8f40302c8/12576_2023_880_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/94cbffcdd263/12576_2023_880_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/fd737b1dddbd/12576_2023_880_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/0974acf91870/12576_2023_880_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/8f2051359180/12576_2023_880_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/fb590ca97874/12576_2023_880_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1c3b/10717292/bff8f40302c8/12576_2023_880_Fig6_HTML.jpg

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