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血浆 8-OHdG 可作为激素诱导性股骨头坏死的生物标志物。

Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head.

机构信息

Guangzhou University of Chinese Medicine, Guangzhou, 510405, China.

Guangdong Research Institute for Orthopedics and Traumatology of Chinese Medicine, Guangzhou, 510378, China.

出版信息

BMC Musculoskelet Disord. 2023 Oct 12;24(1):808. doi: 10.1186/s12891-023-06804-0.

DOI:10.1186/s12891-023-06804-0
PMID:37828532
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10568778/
Abstract

BACKGROUND

Oxidative stress was closely related to the occurrence and development of Steroid-induced osteonecrosis of the femoral head (SIONFH). 8-hydroxy-2'-deoxyguanosine (8-OHdG) is a important index of oxidative stress. The aim of this study is to investigate the role of 8-OHdG in the development of SIONFH.

METHODS

From May 2021 and November 2021, 33 patients diagnosed with SIONFH and 26 healthy controls were recruited in this study. Assessment included the radiography and pathology evaluation of clinical bone tissue, expression position and level of 8-OHdG, level of plasma 8-OHdG, as well as the receiver operating characteristic (ROC) curve.

RESULTS

We observed that expression levels of 8-OHdG in bone samples decreased with Association Research Circulation Osseous (ARCO) stages. Plasma 8-OHdG levels were significantly increased in the SIONFH group compared to the healthy control group. Plasma 8-OHdG level of pre-collapse patients was higher than that of post-collapse patients, the decreased plasma 8-OHdG level was related to higher ARCO stages.

CONCLUSION

Plasma 8-OHdG may represent potential biomarkers during SIONFH at different stages. Higher plasma 8-OHdG levels indicated early stage of SIONFH. The current study provided new clues for early diagnosis and treatment for SIONFH.

摘要

背景

氧化应激与激素性股骨头坏死（SIONFH）的发生和发展密切相关。8-羟基-2'-脱氧鸟苷（8-OHdG）是氧化应激的重要指标。本研究旨在探讨 8-OHdG 在 SIONFH 发展中的作用。

方法

本研究纳入了 2021 年 5 月至 2021 年 11 月期间被诊断为 SIONFH 的 33 名患者和 26 名健康对照者。评估包括临床骨组织的影像学和病理学评估、8-OHdG 的表达位置和水平、血浆 8-OHdG 水平以及受试者工作特征（ROC）曲线。

结果

我们观察到骨样本中 8-OHdG 的表达水平随着 Association Research Circulation Osseous（ARCO）分期的增加而降低。SIONFH 组的血浆 8-OHdG 水平明显高于健康对照组。塌陷前患者的血浆 8-OHdG 水平高于塌陷后患者，血浆 8-OHdG 水平降低与 ARCO 分期较高有关。

结论

血浆 8-OHdG 可能代表 SIONFH 不同阶段的潜在生物标志物。较高的血浆 8-OHdG 水平提示 SIONFH 的早期阶段。本研究为 SIONFH 的早期诊断和治疗提供了新的线索。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/6fb5dbadf0c3/12891_2023_6804_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/2d9dfa6735d2/12891_2023_6804_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/1e338f248a95/12891_2023_6804_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/8948b107f543/12891_2023_6804_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/c735fbe36496/12891_2023_6804_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/dbcaa89b7f4c/12891_2023_6804_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/6fb5dbadf0c3/12891_2023_6804_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/2d9dfa6735d2/12891_2023_6804_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/1e338f248a95/12891_2023_6804_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/8948b107f543/12891_2023_6804_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/c735fbe36496/12891_2023_6804_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/dbcaa89b7f4c/12891_2023_6804_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a5cc/10568778/6fb5dbadf0c3/12891_2023_6804_Fig6_HTML.jpg

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